caa a22 4500 386400199 CHVBK 20180307112155.0 cr unu---uuuuu 161130e198904 xx s 000 0 eng 10.1017/S0031182000062211 doi S0031182000062211 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000062211 Action of cyclosporin A on the tapeworms Hymenolepis microstoma, H. diminuta and Mesocestoides corti in vivo [Elektronische Daten] The in vivo activity of two cyclosporins, cyclosporin A (CsA) and a non-immunosuppressive derivative of dihydrocylosporin A (DHCsA-d) against three tapeworms, Hymenolepis microstoma, H. diminuta and Mesocestoides corti, has been assessed. CsA reversibly reduced the dry weight of H. microstoma in the mouse, briefly delayed oviposition and had a statistically significant effect on worm numbers recovered. Oral and subcutaneous treatments of both CsA and DHCsA-d were effective in reducing worm weight; juvenile worms were most susceptible but worms of all ages responded to drug by a dramatic reduction in weight from which they recovered. Multiple courses of CsA were no more active than single courses of treatment but dose response suggested that a threshold level of drug was necessary to evoke activity. By contrast, H. diminuta in the rat was completely unaffected by CsA but no explanation for the differences in drug response by these two closely related helminths is forthcoming. Mesocestoides corti responded reversibly to CsA in the mouse by a reduction in asexual proliferation of both liver and peritoneal cavity tetrathyridia. The data presented argue in favour of a range of anti-parasitic activities by cyclosporins but the details of the various putative modes of action remain to be defined. Copyright © Cambridge University Press 1989 cyclosporin A nationallicence Hymenolepis microstoma nationallicence Hymenolepis diminuta nationallicence Mesocestoides corti nationallicence Chappell L. H. Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN Wastling J. M. Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN Hurd Hilary Department of Biological Sciences, University of Keele, Keele ST5 5BG Parasitology Cambridge University Press 98/2(1989-04), 291-299 0031-1820 98:2<291 1989 98 PAR https://doi.org/10.1017/S0031182000062211 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000062211 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chappell L. H. Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN NATIONALLICENCE 700 1- Wastling J. M. Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN NATIONALLICENCE 700 1- Hurd Hilary Department of Biological Sciences, University of Keele, Keele ST5 5BG NATIONALLICENCE 773 0- Parasitology Cambridge University Press 98/2(1989-04), 291-299 0031-1820 98:2<291 1989 98 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge