caa a22 4500 386400261 CHVBK 20180307112156.0 cr unu---uuuuu 161130e198912 xx s 000 0 eng 10.1017/S0031182000059084 doi S0031182000059084 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000059084 Schistosoma mansoni: evidence that ‘non-permissiveness' in 129/Ola mice involves worm relocation and attrition in the lungs [Elektronische Daten] 129/Ola mice resemble WEHI 129J mice in that around 70% of the individuals in any given population resist a primary infection with Schistosoma mansoni. Squashed-organ autoradiographic tracking of [Se]selenomethionine-labelled parasites has shown that the kinetics of worm migration in 129/Ola mice follows the expected pattern, and that all rodents harbour essentially similar numbers of worms on day 14 post-infection. Combined lung and liver worm recovery techniques have revealed, however, that segregation of mice into ‘permissive' and ‘non-permissive' individuals can first be detected on day 20. ‘Non-permissive' mice are characterized by the absence of schistosome eggs at all times in the liver parenchyma and, in consequence, lack the attendant manifestations of pathology; they do, however, harbour a few stunted worms in the liver and significant numbers of adult schistosomes in the pulmonary vasculature. Histological analysis of sectioned lung tissue from such animals indicates that some lung-located schistosomes feed, pair and lay eggs. Nevertheless, eosinophil-enriched inflammatory reactions develop around such worms and the parasites themselves exhibit various manifestations of trauma, ranging from minor vacuolation to gut herniation and extrusion. The phenomenon of ‘non-permissiveness' thus involves retardation of worm development in the liver and, in consequence, relocation of the parasites to the lungs, where they become subject to host effector responses. Copyright © Cambridge University Press 1989 Schistosoma mansoni nationallicence 129/Ola mice nationallicence non-permissiveness nationallicence autoradiographic tracking nationallicence relocation nationallicence lung inflammation nationallicence Elsaghier A. A. F. National Institute for Medical Research, Mill Hill, London NW7 1A A, UK Knopf P. M. Brown University, Rhode Island, USA Mitchell G. F. Walter & Eliza Hall Institute of Medical Research, Melbourne, Australia Mclaren D. J. National Institute for Medical Research, Mill Hill, London NW7 1A A, UK Parasitology Cambridge University Press 99/3(1989-12), 365-375 0031-1820 99:3<365 1989 99 PAR https://doi.org/10.1017/S0031182000059084 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000059084 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elsaghier A. A. F. National Institute for Medical Research, Mill Hill, London NW7 1A A, UK NATIONALLICENCE 700 1- Knopf P. M. Brown University, Rhode Island, USA NATIONALLICENCE 700 1- Mitchell G. F. Walter & Eliza Hall Institute of Medical Research, Melbourne, Australia NATIONALLICENCE 700 1- Mclaren D. J. National Institute for Medical Research, Mill Hill, London NW7 1A A, UK NATIONALLICENCE 773 0- Parasitology Cambridge University Press 99/3(1989-12), 365-375 0031-1820 99:3<365 1989 99 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge