caa a22 4500 38640027X CHVBK 20180307112156.0 cr unu---uuuuu 161130e198912 xx s 000 0 eng 10.1017/S0031182000059011 doi S0031182000059011 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000059011 Plasmodium falciparum growth inhibition by human platelets in vitro [Elektronische Daten] Platelets take an active part in immunological processes as well as in haemostasis, especially in the host-parasite relationship. Our aim is to assess the growth of Plasmodium falciparum, cultured in human erythrocytes in the presence of fresh washed human platelets, since thrombocytopaenia is frequently observed during malarial infections. Our results show that platelets induce a dose-related growth inhibition of P. falciparum. Both proliferation and maturation of intraerythrocytic stages of the parasite are inhibited. This growth inhibition is triggered by the parasite itself as neither specific antibodies nor any other components are needed to activate platelets. Activated platelets are directly toxic since complement is not involved. Furthermore, inhibition is not mediated by erythrocyte lysis or by toxic oxygen metabolites. Platelets induce an inhibition of P.falciparum growth, at least in vitro, although the importance of their role played in vivo in malarial immunity has yet to be evaluated. Copyright © Cambridge University Press 1989 Plasmodium falciparum nationallicence growth inhibition, platelets nationallicence platelets nationallicence Peyron F. Laboratoire de Parasitologie (CNRS URA 1344), Faculté de Méedecine de Grenoble, 38700 La Tranche, France Polack B. Laboratoire d'Hématologie, Centre Hospitaller Universitaire de Grenoble, BP 217X, 38043 Grenoble CEDEX, France Lamotte D. Laboratoire d'Hématologie, Centre Hospitaller Universitaire de Grenoble, BP 217X, 38043 Grenoble CEDEX, France Kolodie L. Laboratoire d'Hématologie, Centre Hospitaller Universitaire de Grenoble, BP 217X, 38043 Grenoble CEDEX, France Ambroise-Thomas P. Laboratoire de Parasitologie (CNRS URA 1344), Faculté de Méedecine de Grenoble, 38700 La Tranche, France Parasitology Cambridge University Press 99/3(1989-12), 317-322 0031-1820 99:3<317 1989 99 PAR https://doi.org/10.1017/S0031182000059011 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000059011 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Peyron F. Laboratoire de Parasitologie (CNRS URA 1344), Faculté de Méedecine de Grenoble, 38700 La Tranche, France NATIONALLICENCE 700 1- Polack B. Laboratoire d'Hématologie, Centre Hospitaller Universitaire de Grenoble, BP 217X, 38043 Grenoble CEDEX, France NATIONALLICENCE 700 1- Lamotte D. Laboratoire d'Hématologie, Centre Hospitaller Universitaire de Grenoble, BP 217X, 38043 Grenoble CEDEX, France NATIONALLICENCE 700 1- Kolodie L. Laboratoire d'Hématologie, Centre Hospitaller Universitaire de Grenoble, BP 217X, 38043 Grenoble CEDEX, France NATIONALLICENCE 700 1- Ambroise-Thomas P. Laboratoire de Parasitologie (CNRS URA 1344), Faculté de Méedecine de Grenoble, 38700 La Tranche, France NATIONALLICENCE 773 0- Parasitology Cambridge University Press 99/3(1989-12), 317-322 0031-1820 99:3<317 1989 99 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge