caa a22 4500 386400318 CHVBK 20180307112156.0 cr unu---uuuuu 161130e198912 xx s 000 0 eng 10.1017/S0031182000059096 doi S0031182000059096 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000059096 Schistosoma mansoni: evidence that vascular abnormalities correlate with the ‘non- permissive' trait in 129/Ola mice [Elektronische Daten] The pulmonary and portal vasculature of naïve mice of the 129/Ola and CBA/Ca strains has been studied by means of the vasculature casting technique. This involves injection of pigmented vinylite resin into the arterial and venous systems, followed by digestion of the tissues with KOH. The peripheral vessels of the arterial and portal systems of CBA/Ca mice were numerous and highly branched. In contrast, casts prepared from 70-80% of naïve 129/Ola mice showed dramatic reductions in the number and extent of the peripheral vessels. In addition, such vessels appeared severely truncated. The remaining 20-30% of naïve 129/Ola mice yielded lung and liver casts that were indistinguishable from the CBA/Ca casts. Casts prepared from 129/Ola mice infected 6 weeks previously with Schistosoma mansoni cercariae showed the same segregation; faecal smears, together with observations of presence or absence of gross pathology in such mice confirmed that the vascular changes correlated with the ‘non-permissive trait'. We propose that such alterations facilitate the reportedly abnormal migration of schistosomes from the liver to the lungs in ‘non-permissive' 129/Ola mice. Copyright © Cambridge University Press 1989 129/Ola mice nationallicence Schistosoma mansoni nationallicence ‘non-permissiveness' nationallicence vasculature casting nationallicence migration nationallicence Elsaghier A. A. F. Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA Mclaren D. J. Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA Parasitology Cambridge University Press 99/3(1989-12), 377-381 0031-1820 99:3<377 1989 99 PAR https://doi.org/10.1017/S0031182000059096 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000059096 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elsaghier A. A. F. Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA NATIONALLICENCE 700 1- Mclaren D. J. Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA NATIONALLICENCE 773 0- Parasitology Cambridge University Press 99/3(1989-12), 377-381 0031-1820 99:3<377 1989 99 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge