caa a22 4500 386400342 CHVBK 20180307112156.0 cr unu---uuuuu 161130e198912 xx s 000 0 eng 10.1017/S0031182000059138 doi S0031182000059138 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000059138 Effects of potential inhibitors on Brugia pahangi in vitro: macrofilaricidal action and inhibition of microfilarial production [Elektronische Daten] A series of compounds that apparently disrupt hormonally regulated processes in insects have been examined for effects on the viability and microfilarial production of adult Brugia pahangi cultured in vitro. The azasteroids, 25-azacoprostane and 25-azacholestane, inhibited the production of microfilariae at 5 ppm, the former also exhibiting macrofilaricidal activity at this concentration. The brassinosteroids examined inhibited microfilarial production at 5 ppm but did not affect worm viability. Azadirachtin also proved to be a significant inhibitor of microfilarial release without effect on worm motility or viability. Of all the compounds tested, the non-steroidal amines appeared to be the most promising as potential filaricides, several of them proving to be macrofilaricidal at 1 ppm and affecting microfilarial production at even lower concentrations. Copyright © Cambridge University Press 1989 Brugia pahangi nationallicence hormones nationallicence azasteroids nationallicence brassinosteroids nationallicence non-steroidal amines nationallicence reproduction nationallicence Barker G. C. The Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK Mercer J. G. The Department of Biochemistry, University of Liverpool, Liverpool L69 3BX, UK Svoboda J. A. Insect and Nematode Hormone Laboratory, B.A.R.C, U.S.D.A., Beltsville, MD 20705, USA Thompson M. J. Insect and Nematode Hormone Laboratory, B.A.R.C, U.S.D.A., Beltsville, MD 20705, USA Rees H. H. The Department of Biochemistry, University of Liverpool, Liverpool L69 3BX, UK Howells R. E. The Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK Parasitology Cambridge University Press 99/3(1989-12), 409-416 0031-1820 99:3<409 1989 99 PAR https://doi.org/10.1017/S0031182000059138 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000059138 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barker G. C. The Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK NATIONALLICENCE 700 1- Mercer J. G. The Department of Biochemistry, University of Liverpool, Liverpool L69 3BX, UK NATIONALLICENCE 700 1- Svoboda J. A. Insect and Nematode Hormone Laboratory, B.A.R.C, U.S.D.A., Beltsville, MD 20705, USA NATIONALLICENCE 700 1- Thompson M. J. Insect and Nematode Hormone Laboratory, B.A.R.C, U.S.D.A., Beltsville, MD 20705, USA NATIONALLICENCE 700 1- Rees H. H. The Department of Biochemistry, University of Liverpool, Liverpool L69 3BX, UK NATIONALLICENCE 700 1- Howells R. E. The Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK NATIONALLICENCE 773 0- Parasitology Cambridge University Press 99/3(1989-12), 409-416 0031-1820 99:3<409 1989 99 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge