caa a22 4500 386400407 CHVBK 20180307112156.0 cr unu---uuuuu 161130e198912 xx s 000 0 eng 10.1017/S0031182000059163 doi S0031182000059163 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000059163 Repair of Hymenolepis diminuta after complement-mediated damage [Elektronische Daten] Seven and 56-day-old Hymenolepis diminuta were exposed to complement by incubation in 50% normal rat serum (NRS) in modified Hanks' saline. Ultrastructural studies revealed that the scolex/neck region remained relatively intact whilst in the strobila region microthrix denudation and loss of distal cytoplasm were observed. When complement-mediated damaged worms were incubated in vitro in 50% heat-inactivated normal rat serum (hiNRS) plus M199 or implanted into the duodenum of NMRI mice repair occurred, although destrobilated parasites were only found in vivo. The regions undergoing repair contained tegumental protrusions, vesicles, large electron-lucent areas and large quantities of lipid. Microtriches were formed parallel to the parasite surface and were raised into a perpendicular position. It is suggested that the regenerative process exhibited after complement-mediated damage does not mimic totally the embryological development of the surface layer. Copyright © Cambridge University Press 1989 Hymenolepis diminuta nationallicence complement-mediated damage nationallicence destrobilation nationallicence microthrix development nationallicence repair nationallicence Andreassen J. Department of Parasitology, Institute of Population Biology, University of Copenhagen, Universitetsparken 15, DK2100, Copenhagen, Denmark Hoole D. Department of Parasitology, Institute of Population Biology, University of Copenhagen, Universitetsparken 15, DK2100, Copenhagen, Denmark Parasitology Cambridge University Press 99/3(1989-12), 437-443 0031-1820 99:3<437 1989 99 PAR https://doi.org/10.1017/S0031182000059163 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000059163 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andreassen J. Department of Parasitology, Institute of Population Biology, University of Copenhagen, Universitetsparken 15, DK2100, Copenhagen, Denmark NATIONALLICENCE 700 1- Hoole D. Department of Parasitology, Institute of Population Biology, University of Copenhagen, Universitetsparken 15, DK2100, Copenhagen, Denmark NATIONALLICENCE 773 0- Parasitology Cambridge University Press 99/3(1989-12), 437-443 0031-1820 99:3<437 1989 99 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge