caa a22 4500 386400644 CHVBK 20180307112157.0 cr unu---uuuuu 161130e198906 xx s 000 0 eng 10.1017/S003118200006145X doi S003118200006145X pii (NATIONALLICENCE)cambridge-10.1017/S003118200006145X Chloroquine containing liposomes in the chemotherapy of murine malaria [Elektronische Daten] In this study, the advantage of the use of chloroquine (CQ) containing liposomes (lipCQ) over free CQ in the chemotherapy of murine malaria (Plasmodium berghei) was demonstrated. The maximum permissible dose per intraperitoneal injection was 0·8 and 10 mg for CQ and lipCQ, respectively. An increase in therapeutic and prophylactic efficacy of lipCQ in comparison with free CQ at a 0·8 mg CQ dose level was found. It was possible to obtain 100% efficacy (injection at day 5 after infection; parasitaemia 4-8%) with one single intraperitoneal injection of 6 mg lipCQ. Moreover, the ability to increase the doses of CQ per injection after liposome encapsulation allowed successful treatment of infections with CQ-resistant Plasmodium berghei which could not be cured by a 7-day course with the maximum tolerable dose of free CQ of 0·8 mg/mouse/day. Copyright © Cambridge University Press 1989 Liposome encapsulated chloroquine nationallicence Plasmodium berghei infections nationallicence sustained release nationallicence chemotherapy nationallicence Peeters P. A. M. Department of Pharmaceutics, Faculty of Pharmacy, University of Utrecht, Croesestraat 79, 3522 AD Utrecht, The Netherlands Huiskamp Caroline W. E. M. Department of Pharmaceutics, Faculty of Pharmacy, University of Utrecht, Croesestraat 79, 3522 AD Utrecht, The Netherlands Eling W. M. C. Department of Cell Biology and Histology, University of Nijmegen, 6500 HB Nijmegen, The Netherlands Crommelin D. J. A. Department of Pharmaceutics, Faculty of Pharmacy, University of Utrecht, Croesestraat 79, 3522 AD Utrecht, The Netherlands Parasitology Cambridge University Press 98/3(1989-06), 381-386 0031-1820 98:3<381 1989 98 PAR https://doi.org/10.1017/S003118200006145X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S003118200006145X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Peeters P. A. M. Department of Pharmaceutics, Faculty of Pharmacy, University of Utrecht, Croesestraat 79, 3522 AD Utrecht, The Netherlands NATIONALLICENCE 700 1- Huiskamp Caroline W. E. M. Department of Pharmaceutics, Faculty of Pharmacy, University of Utrecht, Croesestraat 79, 3522 AD Utrecht, The Netherlands NATIONALLICENCE 700 1- Eling W. M. C. Department of Cell Biology and Histology, University of Nijmegen, 6500 HB Nijmegen, The Netherlands NATIONALLICENCE 700 1- Crommelin D. J. A. Department of Pharmaceutics, Faculty of Pharmacy, University of Utrecht, Croesestraat 79, 3522 AD Utrecht, The Netherlands NATIONALLICENCE 773 0- Parasitology Cambridge University Press 98/3(1989-06), 381-386 0031-1820 98:3<381 1989 98 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge