caa a22 4500 388033010 CHVBK 20180307124957.0 cr unu---uuuuu 161130e199805 xx s 000 0 eng 10.1086/647830 doi S0195941700087671 pii (NATIONALLICENCE)cambridge-10.1086/647830 Microbiological Hazards Related to Xenotransplantation of Porcine Organs Into Man [Elektronische Daten] Pigs are emerging as the most likely providers of genetically engineered organs and cells for the purpose of clinical xenotransplantation. Introduction of clinical trials has been delayed primarily by uncertainties regarding the risk of swine pathogen transmission that could harm the recipient. The concern that xenotransplantation carries the potential for a new epidemic has been highlighted by recent experiences with both bovine spongiform encephalopathy and human immunodeficiency diseases. As clinical trials have been postponed and xenotransplantation teams are working actively to gather data for an estimation of the risk, this review provides the reader with a state-of-the-art estimation of the microbiological hazards related to xenotransplantation of porcine organs to man. Particular emphasis is put on viral and retroviral hazards. Both current diagnostic tools and those under development are described, along with breeding strategies to provide donor animals that would not put the recipient or the general population at risk Copyright © The Society for Healthcare Epidemiology of America 1998 Borie Dominic C. Department of Hepato-Biliary Surgery and Liver Transplantation, Groupe Hospitalier Pitié-Salpêtrière, Paris, France Cramer Donald V. Transplantation Biology Research Laboratory, St. Vincent Medical Center, Los Angeles, California Phan-Thanh Luu Infectious Diseases and Immunology, PII, Institut National de la Recherche Agronomique, Nouzilly, France Vaillant Jean Christophe Department of Hepato-Biliary Surgery and Liver Transplantation, Groupe Hospitalier Pitié-Salpêtrière, Paris, France Bequet Jean Louis Charles River Laboratories, Saint-Aubin-Les-Elbeuff, France Makowka Leonard Transplantation Biology Research Laboratory, St. Vincent Medical Center, Los Angeles, California Hannoun Laurent Department of Hepato-Biliary Surgery and Liver Transplantation, Groupe Hospitalier Pitié-Salpêtrière, Paris, France Infection Control & Hospital Epidemiology Cambridge University Press 19/5(1998-05), 355-365 0899-823X 19:5<355 1998 19 ICE https://doi.org/10.1086/647830 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1086/647830 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Borie Dominic C. Department of Hepato-Biliary Surgery and Liver Transplantation, Groupe Hospitalier Pitié-Salpêtrière, Paris, France NATIONALLICENCE 700 1- Cramer Donald V. Transplantation Biology Research Laboratory, St. Vincent Medical Center, Los Angeles, California NATIONALLICENCE 700 1- Phan-Thanh Luu Infectious Diseases and Immunology, PII, Institut National de la Recherche Agronomique, Nouzilly, France NATIONALLICENCE 700 1- Vaillant Jean Christophe Department of Hepato-Biliary Surgery and Liver Transplantation, Groupe Hospitalier Pitié-Salpêtrière, Paris, France NATIONALLICENCE 700 1- Bequet Jean Louis Charles River Laboratories, Saint-Aubin-Les-Elbeuff, France NATIONALLICENCE 700 1- Makowka Leonard Transplantation Biology Research Laboratory, St. Vincent Medical Center, Los Angeles, California NATIONALLICENCE 700 1- Hannoun Laurent Department of Hepato-Biliary Surgery and Liver Transplantation, Groupe Hospitalier Pitié-Salpêtrière, Paris, France NATIONALLICENCE 773 0- Infection Control & Hospital Epidemiology Cambridge University Press 19/5(1998-05), 355-365 0899-823X 19:5<355 1998 19 ICE CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge