caa a22 4500 388033355 CHVBK 20180307124958.0 cr unu---uuuuu 161130e199807 xx s 000 0 eng 10.1086/647837 doi S0195941700087798 pii (NATIONALLICENCE)cambridge-10.1086/647837 Antimicrobial Use and Resistance in Eight US Hospitals: Complexities of Analysis and Modeling [Elektronische Daten] Abstract OBJECTIVE: To evaluate the relation between antimicrobial use and resistance in intensive-care unit (ICU) and non-ICU inpatient areas in eight US hospitals. METHODS: We determined antimicrobial use in terms of defined daily doses, antimicrobial-use density (defined daily doses/1,000 patient days), and percentage resistance for five antimicrobial-organism combinations in the ICU and non-ICU inpatient areas of eight US hospitals participating in project Intensive Care Antimicrobial Resistance Epidemiology. RESULTS: Antimicrobial resistance and use varied tremendously among the eight hospitals. Antimicrobial resistance among these five nosocomial pathogens was significantly higher within the inpatient setting of these hospitals, compared with the outpatient setting. One hospital consistently ranked highest for use of all classes of antimicrobials examined. High antimicrobial use was not associated necessarily with high resistance for a particular antimicrobial-organism pair. CONCLUSION: Antimicrobial use varied significantly across these hospitals, but generally was higher in ICUs. These results suggest that concomitant surveillance of both antimicrobial resistance and antimicrobial use is helpful in interpreting antimicrobial resistance in a hospital or ICU and that further analysis is required to determine the role of variables other than antimicrobial use in a statistical model for predicting antimicrobial resistance. Copyright © The Society for Healthcare Epidemiology of America 1998 Monnet Dominique L. Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia Archibald Lennox K. Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia Phillips Lisa Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia Tenover Fred C. Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia McGowan John E. Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia Gaynes Robert P. Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia Infection Control & Hospital Epidemiology Cambridge University Press 19/6(1998-07), 388-394 0899-823X 19:6<388 1998 19 ICE https://doi.org/10.1086/647837 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1086/647837 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Monnet Dominique L. Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia NATIONALLICENCE 700 1- Archibald Lennox K. Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia NATIONALLICENCE 700 1- Phillips Lisa Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia NATIONALLICENCE 700 1- Tenover Fred C. Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia NATIONALLICENCE 700 1- McGowan John E. Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia NATIONALLICENCE 700 1- Gaynes Robert P. Hospital Infections Program, Centers for Disease Control and Prevention and the Epidemiology Dept., Rollins School of Public Health of Emory University, Atlanta, Georgia NATIONALLICENCE 773 0- Infection Control & Hospital Epidemiology Cambridge University Press 19/6(1998-07), 388-394 0899-823X 19:6<388 1998 19 ICE CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge