caa a22 4500 388033703 CHVBK 20180307124958.0 cr unu---uuuuu 161130e199810 xx s 000 0 eng 10.1086/647719 doi S0195941700005452 pii (NATIONALLICENCE)cambridge-10.1086/647719 The Relative Efficacy of Respirators and Room Ventilation in Preventing Occupational Tuberculosis [Elektronische Daten] Abstract Objectives: To evaluate the relative efficacy of personal respiratory protection as the concentrations of infectious aerosols increase or as room ventilation rates decrease. Methods: We modified the Wells-Riley mathematical model of airborne transmission of disease by adding a variable for respirator leakage. We modeled three categories of infectiousness using various room ventilation rates and classes of respirators over a 10-hour exposure period. Results: The risk of infection decreases exponentially with increasing room ventilation or with increasing personal respiratory protection. The relative efficacy of personal respiratory protection decreases as room ventilation rates increase or as the concentrations of infectious aerosols decrease. Conclusions: These modeling data suggest that the risk of occupational tuberculosis probably can be lowered considerably by using relatively simple respirators combined with modest room ventilation rates for the infectious aerosols likely to be present in isolation rooms of newly diagnosed patients. However, more sophisticated respirators may be needed to achieve a comparable risk reduction for exposures to more highly concentrated aerosols, such as may be generated during cough-inducing procedures or autopsies involving infectious patients. There is probably minimal benefit to the use of respirators in well-ventilated isolation rooms with patients receiving appropriate therapy Copyright © The Society for Healthcare Epidemiology of America 1998 Fennelly Kevin P. National Jewish Medical and Research Center and the, University of Colorado Health Sciences Center, Denver, Colorado Nardell Edward A. Harvard Medical School and the Cambridge Hospital, Massachusetts Department of Public Health, Boston, Massachusetts Infection Control & Hospital Epidemiology Cambridge University Press 19/10(1998-10), 754-759 0899-823X 19:10<754 1998 19 ICE https://doi.org/10.1086/647719 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1086/647719 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fennelly Kevin P. National Jewish Medical and Research Center and the, University of Colorado Health Sciences Center, Denver, Colorado NATIONALLICENCE 700 1- Nardell Edward A. Harvard Medical School and the Cambridge Hospital, Massachusetts Department of Public Health, Boston, Massachusetts NATIONALLICENCE 773 0- Infection Control & Hospital Epidemiology Cambridge University Press 19/10(1998-10), 754-759 0899-823X 19:10<754 1998 19 ICE CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge