caa a22 4500 388034041 CHVBK 20180307124959.0 cr unu---uuuuu 161130e199804 xx s 000 0 eng 10.1017/S0195941700087300 doi S0195941700087300 pii (NATIONALLICENCE)cambridge-10.1017/S0195941700087300 Comparison of Vancomycin and Cefuroxime for Infection Prophylaxis in Coronary Artery Bypass Surgery [Elektronische Daten] OBJECTIVE: To investigate clinically significant differences between vancomycin and cefuroxime for perioperative infection prophylaxis in coronary artery bypass surgery. DESIGN: A total of 884 patients were randomized prospectively to receive either cefuroxime (444) or van-comycin (440) and were assessed for infectious complications during hospitalization and 1 month postoperatively. SETTING: A university hospital. RESULTS: The overall immediate surgical-site infection rate was 3.2% in the cefuroxime group and 3.5% in the vancomycin group (difference, −0.3; 95% confidence interval, −2.6-2.1). CONCLUSIONS: The data suggest that vancomycin has no clinically significant advantages over cephalosporin in terms of antimicrobial prophylaxis. We suggest that cefuroxime (or first-generation cephalosporins, which were not studied here) is a good choice for infection prophylaxis in connection with coronary artery bypass surgery in institutions without methicillin-resistant Staphylococcus aureus problems. In addition to the increasing vancomycin-resistant enterococci problem, the easier administration and usually lower price of cefuroxime make it preferable to vancomycin. Copyright © The Society for Healthcare Epidemiology of America 1998 Vuorisalo Sailaritta Department of Surgery, University of Oulu Pokela Risto Department of Surgery, University of Oulu Syrjälä Hannu Department of Infection Control, Oulu University Hospital, Oulu, Finland Infection Control Cambridge University Press 19/4(1998-04), 234-239 0195-9417 19:4<234 1998 19 ICE https://doi.org/10.1017/S0195941700087300 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0195941700087300 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vuorisalo Sailaritta Department of Surgery, University of Oulu NATIONALLICENCE 700 1- Pokela Risto Department of Surgery, University of Oulu NATIONALLICENCE 700 1- Syrjälä Hannu Department of Infection Control, Oulu University Hospital, Oulu, Finland NATIONALLICENCE 773 0- Infection Control Cambridge University Press 19/4(1998-04), 234-239 0195-9417 19:4<234 1998 19 ICE CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge