caa a22 4500 38803419X CHVBK 20180307125000.0 cr unu---uuuuu 161130e199808 xx s 000 0 eng 10.1086/647876 doi S0195941700088445 pii (NATIONALLICENCE)cambridge-10.1086/647876 Gerberding Julie Louise San Francisco General Hospital, San Francisco, California Nosocomial Transmission of Opportunistic Infections [Elektronische Daten] [Julie Louise Gerberding] Immunocompromised patients are at high risk for opportunistic infections. Traditionally, these infections were thought to arise from endogenous reactivation of previously acquired latent infections, and nosocomial transmission therefore was deemed to be so unlikely that no special infection control interventions were needed to prevent transmission in healthcare settings. However, new data have challenged this view and suggest that some opportunistic pathogens are transmissible from one immunosuppressed patient to another. Epidemiological investigations, molecular genotyping, animal studies, and air-sampling experiments lend support to the hypothesis that reinfection with opportunistic pathogens does occur, that airborne transmission is possible, and that nosocomial spread is a plausible explanation for case clusters. Taken together, these observations support the view that some opportunistic infections are exogenous in origin and that additional epidemiological investigations are needed to define the true risk of nosocomial spread and need for isolation. Copyright © The Society for Healthcare Epidemiology of America 1998 Infection Control & Hospital Epidemiology Cambridge University Press 19/8(1998-08), 574-577 0899-823X 19:8<574 1998 19 ICE https://doi.org/10.1086/647876 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1086/647876 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Gerberding Julie Louise San Francisco General Hospital, San Francisco, California NATIONALLICENCE 773 0- Infection Control & Hospital Epidemiology Cambridge University Press 19/8(1998-08), 574-577 0899-823X 19:8<574 1998 19 ICE CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge