caa a22 4500 388034459 CHVBK 20180307125000.0 cr unu---uuuuu 161130e199801 xx s 000 0 eng 10.1086/647704 doi S0195941700000114 pii (NATIONALLICENCE)cambridge-10.1086/647704 Risk Factors for Mortality in Staphylococcus aureus Bacteremia [Elektronische Daten] Abstract Objective: To analyze risk factors for, and the role of methicillin resistance in, mortality in Staphylococcus aureus bacteremia. Design: Nested case-control study. Setting: General teaching hospital with a high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) strains, in São Paulo, Brazil. Patients: 136 patients over 14 years old with documented S aureus bacteremia. Those who died were compared with those who survived at least 14 days. Results: Mortality within 14 days of bacteremia was 39% (53/136). Mean age was 47 years. Hospital-acquired bacteremia represented 86% (117/136) of episodes. In 26% (35/136), infection was related to an intravascular catheter and in 13% (17/136) to the respiratory tract. Septic shock occurred in 22% (30/136) of cases. MRSA was isolated in 66% (90/136). Multivariate analysis identified three variables that were significantly and independently associated with mortality: site of entry (lung, odds ratio [OR], 17.0; unknown, OR, 12.3; others, OR, 6.6); occurrence of shock (OR, 8.9), and resistance of S aureus to methicillin (OR, 4.2). Conclusion: Our study shows that S aureus bacteremia has a high mortality, especially when the lung is the source of infection and when shock develops; resistance to methicillin may be another risk factor for poor outcome. Copyright © The Society for Healthcare Epidemiology of America 1998 Conterno Lucieni Oliveira Infectious Diseases Division of Marilia Medical School, São Paulo, Brazil Wey Sergio Barsanti Division of Infectious Diseases of São Paulo Federal Medical School-UNIFESP, São Paulo, Brazil Castelo Adauto Division of Infectious Diseases of São Paulo Federal Medical School-UNIFESP, São Paulo, Brazil Infection Control & Hospital Epidemiology Cambridge University Press 19/1(1998-01), 32-37 0899-823X 19:1<32 1998 19 ICE https://doi.org/10.1086/647704 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1086/647704 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Conterno Lucieni Oliveira Infectious Diseases Division of Marilia Medical School, São Paulo, Brazil NATIONALLICENCE 700 1- Wey Sergio Barsanti Division of Infectious Diseases of São Paulo Federal Medical School-UNIFESP, São Paulo, Brazil NATIONALLICENCE 700 1- Castelo Adauto Division of Infectious Diseases of São Paulo Federal Medical School-UNIFESP, São Paulo, Brazil NATIONALLICENCE 773 0- Infection Control & Hospital Epidemiology Cambridge University Press 19/1(1998-01), 32-37 0899-823X 19:1<32 1998 19 ICE CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge