caa a22 4500 388034963 CHVBK 20180307125001.0 cr unu---uuuuu 161130e199809 xx s 000 0 eng 10.1086/647890 doi S0195941700005798 pii (NATIONALLICENCE)cambridge-10.1086/647890 The Risk of Infection Associated With Intra-arterial Catheters for Cancer Chemotherapy [Elektronische Daten] Abstract Objective: To determine the frequency of, and risk factors for, infections associated with intra-arterial catheters used for cancer chemotherapy. Methods: Between September 1992 and September 1995, we conducted a surveillance study of all 807 intra-arterial catheters placed for chemotherapy at our center. The insertion site was disinfected with povidone iodine and alcohol, and the arterial catheter was placed using maximal sterile barrier precautions. Upon removal, all intravascular segments were submitted for semiquantitative culture. Results: No episodes of catheter-related bloodstream infection (95% confidence interval [CI95], 0%-1.6%) were observed. However, the risk of colonization (>15 colony-forming units) of arterial catheters was 15% (CI95, 12%-17%). Retrospective risk-factor analysis conducted on 224 intra-arterial catheters placed for chemotherapy in 1993 showed that colonization was associated significantly with duration of catheterization (median of 1 day for culture-negative catheters vs median of 4 days for culture-positive catheters, P<.001). Age, gender, prior radiotherapy, underlying cancer, neutropenia, and hypoalbuminemia were not associated with catheter colonization. Conclusion: Intra-arterial catheters for cancer chemotherapy placed under maximal sterile barrier precautions for a short period of time are associated with a very low risk of bloodstream infection. Copyright © The Society for Healthcare Epidemiology of America 1998 Raad Issam Department of Medical Specialties, Section of Infection Control, The University of Texas MD Anderson Cancer Center, Houston, Texas Abi-Said Dima Department of Medical Specialties, Sections of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, Texas Carrasco Cesar H. Department of Diagnostic Radiology, Angiography/Interventional Radiology Section, The University of Texas MD Anderson Cancer Center, Houston, Texas Umphrey Jan Department of Medical Specialties, Section of Infection Control, The University of Texas MD Anderson Cancer Center, Houston, Texas Hill Lou Anne Department of Medical Specialties, Section of Infection Control, The University of Texas MD Anderson Cancer Center, Houston, Texas Infection Control & Hospital Epidemiology Cambridge University Press 19/9(1998-09), 640-642 0899-823X 19:9<640 1998 19 ICE https://doi.org/10.1086/647890 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1086/647890 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raad Issam Department of Medical Specialties, Section of Infection Control, The University of Texas MD Anderson Cancer Center, Houston, Texas NATIONALLICENCE 700 1- Abi-Said Dima Department of Medical Specialties, Sections of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, Texas NATIONALLICENCE 700 1- Carrasco Cesar H. Department of Diagnostic Radiology, Angiography/Interventional Radiology Section, The University of Texas MD Anderson Cancer Center, Houston, Texas NATIONALLICENCE 700 1- Umphrey Jan Department of Medical Specialties, Section of Infection Control, The University of Texas MD Anderson Cancer Center, Houston, Texas NATIONALLICENCE 700 1- Hill Lou Anne Department of Medical Specialties, Section of Infection Control, The University of Texas MD Anderson Cancer Center, Houston, Texas NATIONALLICENCE 773 0- Infection Control & Hospital Epidemiology Cambridge University Press 19/9(1998-09), 640-642 0899-823X 19:9<640 1998 19 ICE CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge