caa a22 4500 388058927 CHVBK 20180307125115.0 cr unu---uuuuu 161130e19980801xx s 000 0 eng 10.1375/twin.1.4.196 doi S136905230000043X pii (NATIONALLICENCE)cambridge-10.1375/twin.1.4.196 How heritable is individual susceptibility to death? The results of an analysis of survival data on Danish, Swedish and Finnish twins [Elektronische Daten] Molecular epidemiological studies confirm a substantial contribution of individual genes to variability in susceptibility to disease and death for humans. To evaluate the contribution of all genes to susceptibility and to estimate individual survival characteristics, survival data on related individuals (eg twins or other relatives) are needed. Correlated gamma-frailty models of bivariate survival are used in a joint analysis of survival data on more than 31 000 pairs of Danish, Swedish and Finnish male and female twins using the maximum likelihood method. Additive decomposition of frailty into genetic and environmental components is used to estimate heritability in frailty. The estimate of the standard deviation of frailty from the pooled data is about 1.5. The hypothesis that variance in frailty and correlations of frailty for twins are similar in the data from all three countries is accepted. The estimate of narrow-sense heritability in frailty is about 0.5. The age trajectories of individual hazards are evaluated for all three populations of twins and both sexes. The results of our analysis confirm the presence of genetic infiuences on individual frailty and longevity. They also suggest that the mechanism of these genetic infiuences may be similar for the three Scandinavian countries. Furthermore, results indicate that the increase in individual hazard with age is more rapid than predicted by traditional demographic life tables. Copyright © Cambridge University Press 1998 aging nationallicence frailty nationallicence heritability nationallicence bivariate model nationallicence related individuals nationallicence Iachine Ivan A. Department of Statistics and Demography, Odense University, Denmark. i-iachine@win-chs.ou.dk Holm Niels V. Institute of Community Health, Odense University, Denmark. Harris Jennifer R. Section for Epidemiology, National Institute of Public Health, Oslo, Norway; Division of Genetic Epidemiology, Institute of Environmental Medicine, The Karolinska Institute, Stockholm, Sweden. Begun Alexander Z. Max Planck Institute for Demographic Research, Rostock, Germany. Iachina Maria K. Aging Research Unit, Odense University, Denmark. Laitinen Markku Department of Biology, University of Turku, Finland. Kaprio Jaakko Department of Public Health, University of Helsinki, Finland. Yashin Anatoli I. Max Planck Institute for Demographic Research, Rostock, Germany; Duke University Center for Demographic Studies, Durham, North Carolina, USA. Twin Research Cambridge University Press 1/4(1998-08-01), 196-205 1369-0523 1:4<196 1998 1 THG https://doi.org/10.1375/twin.1.4.196 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1375/twin.1.4.196 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iachine Ivan A. Department of Statistics and Demography, Odense University, Denmark. i-iachine@win-chs.ou.dk NATIONALLICENCE 700 1- Holm Niels V. Institute of Community Health, Odense University, Denmark NATIONALLICENCE 700 1- Harris Jennifer R. Section for Epidemiology, National Institute of Public Health, Oslo, Norway; Division of Genetic Epidemiology, Institute of Environmental Medicine, The Karolinska Institute, Stockholm, Sweden NATIONALLICENCE 700 1- Begun Alexander Z. Max Planck Institute for Demographic Research, Rostock, Germany NATIONALLICENCE 700 1- Iachina Maria K. Aging Research Unit, Odense University, Denmark NATIONALLICENCE 700 1- Laitinen Markku Department of Biology, University of Turku, Finland NATIONALLICENCE 700 1- Kaprio Jaakko Department of Public Health, University of Helsinki, Finland NATIONALLICENCE 700 1- Yashin Anatoli I. Max Planck Institute for Demographic Research, Rostock, Germany; Duke University Center for Demographic Studies, Durham, North Carolina, USA NATIONALLICENCE 773 0- Twin Research Cambridge University Press 1/4(1998-08-01), 196-205 1369-0523 1:4<196 1998 1 THG CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge