caa a22 4500 38805896X CHVBK 20180307125115.0 cr unu---uuuuu 161130e19980201xx s 000 0 eng 10.1375/twin.1.1.15 doi S1369052300000192 pii (NATIONALLICENCE)cambridge-10.1375/twin.1.1.15 Heritability of blood pressure increases during mental stress [Elektronische Daten] We studied the influence of mental stress on the contributions of genes and environment to individual variation in systolic (SBP) and diastolic (DBP) blood pressure by structural equation modelling in 320 adolescent male and female twins. Blood pressure data were collected during rest and during a reaction time and a mental arithmetic task. Univariate analyses of SBP and DBP showed familial aggregation for blood pressure. A genetic explanation for this resemblance was most likely, although during rest conditions a model that attributed familial resemblance to shared environmental factors, also fitted the data. There was no evidence for sex differences in heritabilities. Multivariate analyses showed significant heterogeneity between sexes for the intercorrelations of the blood pressure data measured under different rest and task conditions. Multivariate genetic analyses were therefore carried out separately in males and females. For SBP and DBP in females and for SBP in males an increase in heritabilities was seen for blood pressure measured during stress, as compared to rest measurements. The influence of shared environ-mental factors decreased during stress. For DBP in males no significant contributions of shared environment were found. The multivariate analyses indicated that the same genetic and environmental influences are expressed during rest and stress conditions. Copyright © Cambridge University Press 1998 genetics nationallicence multivariate nationallicence model fitting nationallicence hypertension nationallicence Boomsma DI Department of Physiological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. dorret@psy.vu.nl Snieder H. Department of Physiological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. de Geus EJC Department of Physiological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. van Doornen LJP Department of Physiological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. Twin Research Cambridge University Press 1/1(1998-02-01), 15-24 1369-0523 1:1<15 1998 1 THG https://doi.org/10.1375/twin.1.1.15 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1375/twin.1.1.15 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boomsma DI Department of Physiological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. dorret@psy.vu.nl NATIONALLICENCE 700 1- Snieder H. Department of Physiological Psychology, Vrije Universiteit, Amsterdam, The Netherlands NATIONALLICENCE 700 1- de Geus EJC Department of Physiological Psychology, Vrije Universiteit, Amsterdam, The Netherlands NATIONALLICENCE 700 1- van Doornen LJP Department of Physiological Psychology, Vrije Universiteit, Amsterdam, The Netherlands NATIONALLICENCE 773 0- Twin Research Cambridge University Press 1/1(1998-02-01), 15-24 1369-0523 1:1<15 1998 1 THG CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge