caa a22 4500 38805901X CHVBK 20180307125115.0 cr unu---uuuuu 161130e19980601xx s 000 0 eng 10.1375/twin.1.3.154 doi S1369052300000350 pii (NATIONALLICENCE)cambridge-10.1375/twin.1.3.154 Genetic risk factors in tumours of the testis: lessons from twin studies [Elektronische Daten] A threefold increase for testicular carcinoma has been reported in male dizygotic twins. In this comment we suggest the hypothesis that over-exposure to endogenously hypersecreted Follicle Stimulating Hormone (FSH) may underlie the pathogenesis. This is supported by several findings. 1) FSH hypersecretion in mothers of dizygotic twins is most likely an autosomal trait implicating the possibility of male offspring with the same hormone characteristic. 2) In testicular carcinoma higher levels of cyclin D2 are found. This is an FSH dependent stimulatory regulator of mitosis. 3) There is a marked similarity between geographical distribution in occurence of dizygotic twinning and testicular carcinoma. 4) Men undergoing surgery for testicular carcinoma have higher FSH concentrations and males with Down syndrome have higher FSH levels and are more at risk to develop testicular carcinoma. We suggest to study FSH secretion in males of familial dizygotic twins and furthermore the risk of developing testicular carcinoma in males with elevated FSH. These men with one testicle and/or with dysfunctioning Sertoli/Leydig cells. Copyright © Cambridge University Press 1998 twinning nationallicence testis nationallicence neoplasma nationallicence follicle stimulating hormone nationallicence FSH nationallicence genetics nationallicence geographical distribution nationallicence Lambalk Cornelis B. Division of Reproductive Endocrinology, Research Institute for Endocrinology, Reproduction and Metabolism, Department of Obstetrics/Gynaecology, Academic Hospital, Free University, Amsterdam. cb.lambalk@azvu.nl Boomsma Dorret I. Department of Psychonomics, Faculty of Psychology, Free University, Amsterdam, The Netherlands. Twin Research Cambridge University Press 1/3(1998-06-01), 154-155 1369-0523 1:3<154 1998 1 THG https://doi.org/10.1375/twin.1.3.154 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1375/twin.1.3.154 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lambalk Cornelis B. Division of Reproductive Endocrinology, Research Institute for Endocrinology, Reproduction and Metabolism, Department of Obstetrics/Gynaecology, Academic Hospital, Free University, Amsterdam. cb.lambalk@azvu.nl NATIONALLICENCE 700 1- Boomsma Dorret I. Department of Psychonomics, Faculty of Psychology, Free University, Amsterdam, The Netherlands NATIONALLICENCE 773 0- Twin Research Cambridge University Press 1/3(1998-06-01), 154-155 1369-0523 1:3<154 1998 1 THG CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge