caa a22 4500 388059214 CHVBK 20180307125115.0 cr unu---uuuuu 161130e199812 xx s 000 0 eng 10.1079/PHN19980044 doi S1368980098000457 pii (NATIONALLICENCE)cambridge-10.1079/PHN19980044 Effectiveness of a dietary intervention strategy in general practice: effects on blood lipids, health and well-being [Elektronische Daten] Abstract Objectives: To evaluate the effect of a dietary treatment programme on blood cholesterol concentration in hypercholesterolaemic patients in general practice and to analyse subjectively experienced side-effects. Design: A 1-year parallel trial comparing a new treatment programme with conventional treatment. Setting: General practitioners in Roskilde county, Denmark. Subjects: 355 men and women, aged 20-60 years, with a persistent blood cholesterol concentration above age- and gender-specific cut-off points (265 in an intervention group and 90 in a control group). Intervention: A treatment strategy based on collaboration between doctor and dietitian using individual dietary advice and feedback from measured biological parameters. Main outcome measures: Serum lipids, body weight, blood pressure, dietary behaviour, health parameters, quality of life parameters and acceptance by patients and general practitioners. Results: Total blood cholesterol concentration decreased by 14% (1.07 mmol l−1, P < 0.0001) in 159 patients in the intervention group, not having any lipid altering drug during treatment, in addition to 3% from screening to start of treatment. In 65 patients in the control group, without any lipid altering drug, the reduction of cholesterol concentration was 4% (0.27 mmol l−1, P < 0.01; intervention vs. control P < 0.001). In the intervention group overweight subjects (body mass index > 30) reduced body weight by 6% (P < 0.0001). Systolic blood pressure was reduced by 11% (P < 0.0001) and diastolic blood pressure by 10% (P < 0.0001) and 19% (P < 0.003) for intervals 90-110 mmHg and > 110 mmHg, respectively. Risk score decreased and self-assessed health, physical and psychological well-being improved. Conclusions: The treatment strategy tested proved to be efficient, without side-effects and well accepted by patients and general practitioners. The results strongly suggest that hypercholesterolaemia can efficiently be treated non-pharmacologically in general practice. Copyright © The Nutrition Society 1998 Dietary intervention nationallicence Blood cholesterol nationallicence General practice nationallicence Public health nationallicence Well-being nationallicence Træden UI Institute of Public Health, Department of Social Medicine and Psychosocial Health, University of Copenhagen, Denmark Holm L. Research Department of Human Nutrition, the Royal Veterinary and Agricultural University, Frederiksberg, Denmark Sandström B. Research Department of Human Nutrition, the Royal Veterinary and Agricultural University, Frederiksberg, Denmark Andersen PK Institute of Public Health, Department of Biostatistics, University of Copenhagen, Denmark Jarden M. Institute of Public Health, Department of Biostatistics, University of Copenhagen, Denmark Public Health Nutrition Cambridge University Press 1/4(1998-12), 273-281 1368-9800 1:4<273 1998 1 PHN https://doi.org/10.1079/PHN19980044 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/PHN19980044 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Træden UI Institute of Public Health, Department of Social Medicine and Psychosocial Health, University of Copenhagen, Denmark NATIONALLICENCE 700 1- Holm L. Research Department of Human Nutrition, the Royal Veterinary and Agricultural University, Frederiksberg, Denmark NATIONALLICENCE 700 1- Sandström B. Research Department of Human Nutrition, the Royal Veterinary and Agricultural University, Frederiksberg, Denmark NATIONALLICENCE 700 1- Andersen PK Institute of Public Health, Department of Biostatistics, University of Copenhagen, Denmark NATIONALLICENCE 700 1- Jarden M. Institute of Public Health, Department of Biostatistics, University of Copenhagen, Denmark NATIONALLICENCE 773 0- Public Health Nutrition Cambridge University Press 1/4(1998-12), 273-281 1368-9800 1:4<273 1998 1 PHN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge