caa a22 4500 388059516 CHVBK 20180307125116.0 cr unu---uuuuu 161130e199809 xx s 000 0 eng 10.1079/PHN19980023 doi S136898009800024X pii (NATIONALLICENCE)cambridge-10.1079/PHN19980023 Alcohol consumption and risk of benign proliferative epithelial disorders of the breast: a case-cohort study [Elektronische Daten] Abstract Objective: To study the association between alcohol consumption and risk of benign proliferative epithelial disorders (BPED) of the breast (conditions which are thought to have premalignant potential). Design: Case-cohort study. Setting: The study was undertaken within the 56, 537 women in the Canadian National Breast Screening Study (NBSS) who completed self-administered dietary questionnaires. (The NBSS is a randomized controlled trial of screening for breast cancer in women aged 40-59 years at recruitment.) Subjects: The study subjects were the 657 women in the dietary cohort who were diagnosed with biopsy-confirmed incident BPED. For comparative purposes, a subcohort consisting of a random sample of 5681 women was selected from the full dietary cohort. After exclusions for various reasons, the analyses were based on 557 cases and 5028 non-cases. Results: When compared to non-drinkers, rate ratios (95%CI) for those consuming >0 and ≤10 g of ethanol day−1,>10 and≤20 g day−1, >20 and ≤30 g day1 and >30 g day1 were 0.35(0.27-0.45), 0.26(0.18-0.39), 0.29(0.18-0.48), and 0.23(0.13-0.40), respectively (the associated P value for the trend was 0.089). Similar findings were obtained from analyses conducted separately in the screened and control arms of the NBSS, in premenopausal and postmenopausal women, and for non-atypical and atypical forms of BPED, and there was little difference between the results for screen-detected and interval-detected BPED. Conclusions: Alcohol consumption was associated with a non-dose-dependent reduction in risk of BPED Copyright © The Nutrition Society 1998 Alchol nationallicence Benign breast disease nationallicence Breast cancer nationallicence Rohan Thomas E. Department of Public Health Sciences, University of Toronto, Toronto, Canada Jain Meera Department of Public Health Sciences, University of Toronto, Toronto, Canada Miller Anthony B. Department of Public Health Sciences, University of Toronto, Toronto, Canada Public Health Nutrition Cambridge University Press 1/3(1998-09), 139-145 1368-9800 1:3<139 1998 1 PHN https://doi.org/10.1079/PHN19980023 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/PHN19980023 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rohan Thomas E. Department of Public Health Sciences, University of Toronto, Toronto, Canada NATIONALLICENCE 700 1- Jain Meera Department of Public Health Sciences, University of Toronto, Toronto, Canada NATIONALLICENCE 700 1- Miller Anthony B. Department of Public Health Sciences, University of Toronto, Toronto, Canada NATIONALLICENCE 773 0- Public Health Nutrition Cambridge University Press 1/3(1998-09), 139-145 1368-9800 1:3<139 1998 1 PHN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence SWISSBIB 388059516 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge