caa a22 4500 388060565 CHVBK 20180307125119.0 cr unu---uuuuu 161130e199804 xx s 000 0 eng 10.1017/S135772980000953X doi S135772980000953X pii (NATIONALLICENCE)cambridge-10.1017/S135772980000953X The rôle of cortisol and β-endorphin in the response of the immune system to weaning in lambs [Elektronische Daten] The relationship between weaning stress-induced changes in stress hormone profiles and immune function was investigated in groups of 10 lambs immunized against adrenocorticotrophic hormone (ACTH; treatment A) or fi-endorphin (treatment B) to reduce the circulating concentrations of cortisol and fi-endorphin respectively. Control animals (treatment C) were immunized against a porcine thyroglobulin carrier protein. Application of weaning stress was associated with significantly elevated plasma cortisol concentrations but no significant increase in fi-endorphin concentrations in C lambs. Immunization against ACTH suppressed the post-weaning increase in cortisol concentration. This was associated with a transient reduction in the lymphocyte stimulation response to keyhole limpet haemocyanin (KLH) antigen in the A animals but there was no effect on the antibody response or interferon-y production by antigen stimulated lymphocytes. There were no significant effects of immunization against fi-endorphin on the capacity to mount antibody or cell-mediated immune responses. It is concluded that weaning stress-induced increases in cortisol did not inhibit the immune response. Since cortisol concentrations and the cell mediated immune response at 8 days after immunization were positively associated it is concluded that these indices are not independent measures of stress. Copyright © British Society of Animal Science 1998 immune response nationallicence lambs nationallicence stress nationallicence weaning nationallicence welfare nationallicence Rhind S. M. Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB15 8QH Reid H. W. Moredun Research Institute, 408 Gilmerton Road, Edinburgh EH17 7JH McMillen S. R. Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB15 8QH Palmarini G. Moredun Research Institute, 408 Gilmerton Road, Edinburgh EH17 7JH Animal Science Cambridge University Press 66/2(1998-04), 397-402 1357-7298 66:2<397 1998 66 ASC https://doi.org/10.1017/S135772980000953X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S135772980000953X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rhind S. M. Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB15 8QH NATIONALLICENCE 700 1- Reid H. W. Moredun Research Institute, 408 Gilmerton Road, Edinburgh EH17 7JH NATIONALLICENCE 700 1- McMillen S. R. Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB15 8QH NATIONALLICENCE 700 1- Palmarini G. Moredun Research Institute, 408 Gilmerton Road, Edinburgh EH17 7JH NATIONALLICENCE 773 0- Animal Science Cambridge University Press 66/2(1998-04), 397-402 1357-7298 66:2<397 1998 66 ASC CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge