caa a22 4500 388060913 CHVBK 20180307125120.0 cr unu---uuuuu 161130e199810 xx s 000 0 eng 10.1017/S1357729800010018 doi S1357729800010018 pii (NATIONALLICENCE)cambridge-10.1017/S1357729800010018 A strategy for QTL detection in half-sib populations [Elektronische Daten] A statistical analysis strategy for the detection of quantitative trait loci (QTLs) in half-sib populations is outlined. The initial exploratory analysis is a multiple regression of the trait score on a subset of markers to allow a rapid identification of possible chromosomal regions of interest. This is followed by multiple marker interval mapping with regression methods within and across families fitting one or two QTLs. Empirical thresholds are determined by experiment-wise permutation tests for different significance levels and empirical confidence intervals for the QTLs' positions are obtained by bootstrapping methods. For traits with evidence for a significant single-QTL effect, an approximate maximum likelihood analysis is performed to obtain estimates of QTL effect and the probability of the QTL genotype for each parent of a group of half-sibs. The strategy is demonstrated in an analysis of previously published data on chromosome 6 and five production traits from a granddaughter design in dairy cattle. The results confirm and extend evidence for QTLs affecting protein percentage. Informativeness of markers limited the possibility of mapping more than one QTL on the same linkage group. Copyright © British Society of Animal Science 1998 dairy cattle nationallicence gene mapping nationallicence milk protein nationallicence quantitative trait loci nationallicence Koning D. J. de Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS Visscher P. M. Institute of Ecology and Resource Management, University of Edinburgh, West Mains Road, Edinburgh EH9 3JG Knott S. A. Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT Haley C. S. Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS Animal Science Cambridge University Press 67/2(1998-10), 257-268 1357-7298 67:2<257 1998 67 ASC https://doi.org/10.1017/S1357729800010018 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1357729800010018 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koning D. J. de Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS NATIONALLICENCE 700 1- Visscher P. M. Institute of Ecology and Resource Management, University of Edinburgh, West Mains Road, Edinburgh EH9 3JG NATIONALLICENCE 700 1- Knott S. A. Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT NATIONALLICENCE 700 1- Haley C. S. Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS NATIONALLICENCE 773 0- Animal Science Cambridge University Press 67/2(1998-10), 257-268 1357-7298 67:2<257 1998 67 ASC CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge