caa a22 4500 388061871 CHVBK 20180307125123.0 cr unu---uuuuu 161130e199802 xx s 000 0 eng 10.1017/S0007114598001123 doi S0007114598001123 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001123 Accumulation of cadmium from wheat bran, sugar-beet fibre, carrots and cadmium chloride in the liver and kidneys of mice [Elektronische Daten] The gastrointestinal absorption and organ distribution of Cd after exposure for 9 weeks to three fibre-rich foodstuffs (wheat bran, sugar-beet fibre and carrots) were determined in mice. Groups of eight mice were given a diet containing 0.05 mg Cd/kg from wheat bran, sugar-beet fibre, carrots or CdCl2 mixed in a semi-synthetic, low-Cd (<0.007mg/kg) feed. A control group was fed on the low-Cd semi-synthetic feed. The water consumption, food consumption and the weight of the animals were monitored throughout the study. The feed was changed once weekly and Cd was analysed in the feed at each change. myo-Inositol phosphates (hexa-, penta-, tetra- and tri-) and Zn, Cu, Fe and Ca were also analysed in the diets. After 9 weeks, the mice were killed and liver and kidneys were sampled and analysed for Cd. The group receiving the wheat-bran diet had significantly lower fractional Cd accumulation (% total Cd intake) in the liver and kidneys than the other groups, indicating a lower fractional absorption of Cd. The wheat-bran diet had markedly higher levels of inositol hexa- and pentaphosphates (phytates) and a Zn level that was twice as high as those in the other diets. The higher levels of myo-inositol hexa- and pentaphosphates in the wheat-bran diet most probably contributed more to the lower fractional absorption of Cd than the elevated Zn level, due to the formation of insoluble Cd-phytate complexes. Compared with the wheat-bran diet, the sugar-beet-fibre and carrot diets contained very low levels of myo-inositol penta- and hexaphosphates, and consequently the fractional Cd absorption from these diets was higher. Copyright © The Nutrition Society 1998 Intestinal absorption nationallicence Inositol phosphates nationallicence Dietary fibre nationallicence Trace elements nationallicence Lind Ylva The Swedish National Food Administration, Box 622, S-751 26 Uppsala, Sweden Engman Joakim The Swedish National Food Administration, Box 622, S-751 26 Uppsala, Sweden Jorhem Lars The Swedish National Food Administration, Box 622, S-751 26 Uppsala, Sweden Glynn Anders Wicklund The Swedish National Food Administration, Box 622, S-751 26 Uppsala, Sweden British Journal of Nutrition Cambridge University Press 80/2(1998-02), 205-211 0007-1145 80:2<205 1998 80 BJN https://doi.org/10.1017/S0007114598001123 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001123 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lind Ylva The Swedish National Food Administration, Box 622, S-751 26 Uppsala, Sweden NATIONALLICENCE 700 1- Engman Joakim The Swedish National Food Administration, Box 622, S-751 26 Uppsala, Sweden NATIONALLICENCE 700 1- Jorhem Lars The Swedish National Food Administration, Box 622, S-751 26 Uppsala, Sweden NATIONALLICENCE 700 1- Glynn Anders Wicklund The Swedish National Food Administration, Box 622, S-751 26 Uppsala, Sweden NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/2(1998-02), 205-211 0007-1145 80:2<205 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge