caa a22 4500 388061898 CHVBK 20180307125123.0 cr unu---uuuuu 161130e199802 xx s 000 0 eng 10.1017/S000711459800107X doi S000711459800107X pii (NATIONALLICENCE)cambridge-10.1017/S000711459800107X Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects [Elektronische Daten] We investigated whether the potentiation of postprandial lipaemia by fructose occurs in both non-diabetic subjects and those with non-insulin-dependent diabetes mellitus. Six non-diabetic and six diabetic subjects were studied on two occasions. They were given a meal containing 1 g fat/kg body weight with, on one occasion, 0.75 g fructose/kg body weight, on the other occasion 0.75 g starch/kg body weight. In both groups, plasma glucose and insulin concentrations rose more after starch than after fructose. At 1-2 h after the meal, plasma non-esterified fatty acid concentrations were suppressed more after fructose than after starch, but later they rose more after fructose than after starch. Plasma triacylglycerol concentrations rose more slowly after fructose, but were considerably higher than those after starch from 4-6 h after the meal. There were no differences in post-heparin plasma lipoprotein lipase (EC 3.1.1.34) activity at the end of the test. The potentiation of postprandial lipaemia by fructose was positively related to the fasting plasma insulin concentration, suggesting that insulin-resistant subjects are more prone to this effect. We conclude that the potentiation of postprandial lipaemia by fructose is seen in both diabetic and non-diabetic subjects. Our results suggest that alterations in the dynamics of plasma non-esterified fatty acids might underlie the effects of fructose on triacylglycerol metabolism. Copyright © The Nutrition Society 1998 Fructose nationallicence Postprandial lipaenia nationallicence Non-insulin-dependent diabetes mellitus nationallicence Abraha Arefaine Department of Chemical Pathology, Burnley General Hospital, Casterton Avenue, Burnley BB10 2PQ, UK Humphreys Sandy M. Oxford Lipid Metabolism Group, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK Clark Mo L. Oxford Lipid Metabolism Group, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK Matthews David R. Oxford Centre for Diabetes and Endocrinology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK Frayn Keith N. Oxford Lipid Metabolism Group, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK British Journal of Nutrition Cambridge University Press 80/2(1998-02), 169-175 0007-1145 80:2<169 1998 80 BJN https://doi.org/10.1017/S000711459800107X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S000711459800107X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abraha Arefaine Department of Chemical Pathology, Burnley General Hospital, Casterton Avenue, Burnley BB10 2PQ, UK NATIONALLICENCE 700 1- Humphreys Sandy M. Oxford Lipid Metabolism Group, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK NATIONALLICENCE 700 1- Clark Mo L. Oxford Lipid Metabolism Group, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK NATIONALLICENCE 700 1- Matthews David R. Oxford Centre for Diabetes and Endocrinology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK NATIONALLICENCE 700 1- Frayn Keith N. Oxford Lipid Metabolism Group, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/2(1998-02), 169-175 0007-1145 80:2<169 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge