caa a22 4500 388061944 CHVBK 20180307125123.0 cr unu---uuuuu 161130e199810 xx s 000 0 eng 10.1017/S0007114598001378 doi S0007114598001378 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001378 Regulatory signals in messenger RNA: determinants of nutrient-gene interaction and metabolic compartmentation [Elektronische Daten] Nutrition has marked influences on gene expression and an understanding of the interaction between nutrients and gene expression is important in order to provide a basis for determining the nutritional requirements on an individual basis. The effects of nutrition can be exerted at many stages between transcription of the genetic sequence and production of a functional protein. This review focuses on the role of post-transcriptional control, particularly mRNA stability, translation and localization, in the interactions of nutrients with gene expression. The effects of both macronutrients and micronutrients on regulation of gene expression by post-transcriptional mechanisms are presented and the post-transcriptional regulation of specific genes of nutritional relevance (glucose transporters, transferrin, selenoenzymes, metallothionein, lipoproteins) is described in detail. The function of the regulatory signals in the untranslated regions of the mRNA is highlighted in relation to control of mRNA stability, translation and localization and the importance of these mRNA regions to regulation by nutrients is illustrated by reference to specific examples. The localization of mRNA by signals in the untranslated regions and its function in the spatial organization of protein synthesis is described; the potential of such mechanisms to play a key part in nutrient channelling and metabolic compartmentation is discussed. It is concluded that nutrients can influence gene expression through control of the regulatory signals in these untranslated regions and that the post-transcriptional regulation of gene expression by these mechanisms may influence nutritional requirements. It is emphasized that in studies of nutritional control of gene expression it is important not to focus only on regulation through gene promoters but also to consider the possibility of post-transcriptional control. Copyright © The Nutrition Society 1998 Gene expression nationallicence Untranslated regions nationallicence Post-transcriptional regulation nationallicence Hesketh John E. Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK Vasconcelos M. Helena Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK Bermano Giovanna Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK British Journal of Nutrition Cambridge University Press 80/4(1998-10), 307-321 0007-1145 80:4<307 1998 80 BJN https://doi.org/10.1017/S0007114598001378 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001378 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hesketh John E. Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK NATIONALLICENCE 700 1- Vasconcelos M. Helena Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK NATIONALLICENCE 700 1- Bermano Giovanna Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/4(1998-10), 307-321 0007-1145 80:4<307 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge