caa a22 4500 388062215 CHVBK 20180307125124.0 cr unu---uuuuu 161130e199804 xx s 000 0 eng 10.1079/BJN19980060 doi S0007114598000610 pii (NATIONALLICENCE)cambridge-10.1079/BJN19980060 Maternal nutrition in early-mid gestation and placental size in sheep [Elektronische Daten] We investigated the influence of restricted maternal nutrition between 30 and 80 d gestation on placental growth. Singleton-bearing ewes were fed on either 0.6 (i.e. nutrient restricted) times their energy requirements or 2.25 times this amount (i.e. controls) up to 80 d gestation, when their placentas and fetuses were sampled and analysed. Nutrient-restricted ewes lost body condition score but not body weight and had lower plasma thyroid hormone concentrations than controls, but there were no differences in plasma glucose, non-esterified fatty acids or 3-hydroxybutyrate concentrations between groups. There was no effect of maternal nutrient restriction on fetal weight, conformation or organ weights with the exception of brain weight which was lower in nutrient-restricted ewes. Nutrient restriction had no effect on total placental weight, or proportion of inverted placentomes, but was associated with an increased abundance of small placentomes and decreased weight of the fetal but not maternal components of the placenta. Fetal cotyledons from nutrient-restricted ewes also had a lower DNA but higher haemoglobin concentration than those sampled from controls. The plasma concentration of triiodothyronine in umbilical cord plasma was also increased in fetuses from nutrient-restricted ewes. In conclusion, maternal nutrient restriction during early-mid gestation is associated with a smaller placenta. Copyright © The Nutrition Society 1998 Placenta nationallicence regnancy nationallicence Sheep nationallicence Clarke Lynne School of Animal and Microbial Sciences and University of Reading, Whiteknights, Reading RG6 6AJ, UK Heasman Lindsay Department of Child Health, University Hospital, Queen's Medical School, Nottingham NG7 2UH, UK Juniper Darren T. Department of Agriculture, University of Reading, Whiteknights, Reading RG6 6AJ, UK Symonds Michael E. Department of Child Health, University Hospital, Queen's Medical School, Nottingham NG7 2UH, UK British Journal of Nutrition Cambridge University Press 79/4(1998-04), 359-364 0007-1145 79:4<359 1998 79 BJN https://doi.org/10.1079/BJN19980060 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19980060 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Clarke Lynne School of Animal and Microbial Sciences and University of Reading, Whiteknights, Reading RG6 6AJ, UK NATIONALLICENCE 700 1- Heasman Lindsay Department of Child Health, University Hospital, Queen's Medical School, Nottingham NG7 2UH, UK NATIONALLICENCE 700 1- Juniper Darren T. Department of Agriculture, University of Reading, Whiteknights, Reading RG6 6AJ, UK NATIONALLICENCE 700 1- Symonds Michael E. Department of Child Health, University Hospital, Queen's Medical School, Nottingham NG7 2UH, UK NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 79/4(1998-04), 359-364 0007-1145 79:4<359 1998 79 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge