caa a22 4500 388062282 CHVBK 20180307125124.0 cr unu---uuuuu 161130e199804 xx s 000 0 eng 10.1079/BJN19980056 doi S0007114598000579 pii (NATIONALLICENCE)cambridge-10.1079/BJN19980056 Metal (molybdenum, copper) accumulation and retention in brain, pituitary and other organs of ammonium tetrathiomolybdate-treated sheep [Elektronische Daten] Ammonium tetrathiomolybdate (TTM) is the treatment of choice for chronic Cu poisoning in sheep and is recommended in Wilson's disease. However, the long-term effects have not been fully evaluated and some evidence questions the long-term safety of the drug. The aim of the present study was to investigate the systemic distribution and retention of Cu and Mo in TTM-treated sheep of different breeds and Cu status. Low-Cu Cambridge sheep were divided into a TTM trial group (3·4 mg/kg, subcutaneously, on three alternate days per month, for 5 months) and a control group, and were killed at the end of the course or 7 months later. High-Cu sheep consisting of a Cu-supplemented (150 mg/kg) Cambridge group and a North Ronaldsay group were administered TTM as before and compared with untreated controls. Brain, liver, kidney, heart, skeletal muscle, pituitary, adrenals, testes and ovaries were retained for metal analysis. Mo accumulated in all organs including brain and pituitary (P < 0·02) in all TTM trial groups and was retained after cessation of treatment, except in liver, kidney and skeletal muscle. Cu was increased (P < 0·02) and retained in the cerebellum and medulla oblongata in the TTM-treated high-Cu Cambridge groups. Brain Cu v. Mo concentrations showed a strongly positive correlation (r 0·7) in the high-Cu Ronaldsay group 7 months after TTM treatment. It is concluded that TTM is not all excreted but (Mo) is widely distributed and retained in many organs including brain and pituitary. In addition TTM may redistribute some displaced excess liver Cu (Cu-TTM) to the brain. The consequences of these disturbances await clarification. Copyright © The Nutrition Society 1998 Tetrathiomolybdate nationallicence Molybdenum nationallicence Copper nationallicence Toxicity nationallicence Haywood Susan Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX, UK Dincer Zuhal Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX, UK Holding J. Department of Clinical Chemistry, Duncan Building, Royal University Hospital, Prescot Street, Liverpool L69 3BX, UK Parry Nicola M. Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX, UK British Journal of Nutrition Cambridge University Press 79/4(1998-04), 329-331 0007-1145 79:4<329 1998 79 BJN https://doi.org/10.1079/BJN19980056 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19980056 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Haywood Susan Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX, UK NATIONALLICENCE 700 1- Dincer Zuhal Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX, UK NATIONALLICENCE 700 1- Holding J. Department of Clinical Chemistry, Duncan Building, Royal University Hospital, Prescot Street, Liverpool L69 3BX, UK NATIONALLICENCE 700 1- Parry Nicola M. Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX, UK NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 79/4(1998-04), 329-331 0007-1145 79:4<329 1998 79 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge