caa a22 4500 38806255X CHVBK 20180307125125.0 cr unu---uuuuu 161130e199812 xx s 000 0 eng 10.1017/S0007114598001640 doi S0007114598001640 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001640 Comparison of absorption of nutrients and secretion of water between oligomeric and polymeric enteral diets in pigs [Elektronische Daten] In patients who require enteric tube-feeding the osmolality of the formulas is assumed to play an important role. There is the dilemma that osmolality increases as the digestibility of formulas is enhanced by means of degradation of the nutrients. Hitherto there have been no reports of whether there are differences in nutrient absorption and water fluxes between iso-osmotic polymeric and hyperosmotic oligomeric diets. We therefore investigated absorption of nutrients and net fluxes of water during perfusion of a 1·5 m jejunal segment with oligomeric, polymeric and commercial oligopeptide diets either in the absence of pancreatic juice or with concomitant infusion of pancreatic enzymes. In the absence of pancreatic juice the absorption rates of the polymeric diet and the commercial oligopeptide diets reached 58·0 and 84·5 % respectively of that of a completely-hydrolysed hyperosmotic oligomeric diet. The concomitant infusion of pancreatic enzymes with the polymeric and oligopeptide diets significantly increased the absorption rates of nutrients and energy. The highest absorption rate of energy occurred with the commercial formula Survimed® (Fresenius, Bad Homburg, Germany), probably due to an optimal composition of the macronutrients. The increase in absorption due to the degradation of nutrients by pancreatic enzymes was associated with an increase in net water secretion and flow-rate, reaching similar values to those with the hyperosmotic oligomeric diet. It may be concluded that iso-osmotic oligopeptide formulas require further pancreatic hydrolysis for optimum absorption. In patients with normal pancreatic secretion, oligopeptide formulas have no advantage over polymeric diets. In patients with reduced pancreatic secretion, either completely-hydrolysed hyperosmotic oligomeric diets or polymeric diets supplemented with pancreatic enzymes are appropriate. Copyright © The Nutrition Society 1998 Enteral nutrition nationallicence Osmolality nationallicence Nutrient hydrolysis nationallicence Ehrlein Hansjörg Institute of Physiology, University of Hohenheim, Stuttgart, Germany Haas-Deppe Benedikt Institute of Physiology, University of Hohenheim, Stuttgart, Germany British Journal of Nutrition Cambridge University Press 80/6(1998-12), 545-553 0007-1145 80:6<545 1998 80 BJN https://doi.org/10.1017/S0007114598001640 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001640 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ehrlein Hansjörg Institute of Physiology, University of Hohenheim, Stuttgart, Germany NATIONALLICENCE 700 1- Haas-Deppe Benedikt Institute of Physiology, University of Hohenheim, Stuttgart, Germany NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/6(1998-12), 545-553 0007-1145 80:6<545 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge