caa a22 4500 388062568 CHVBK 20180307125125.0 cr unu---uuuuu 161130e199812 xx s 000 0 eng 10.1017/S0007114598001664 doi S0007114598001664 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001664 Comparison of the effects of fish oil and olive oil on blood lipids and aortic atherosclerosis in Watanabe heritable hyperlipidaemic rabbits [Elektronische Daten] To compare the effects of fish oil and olive oil on the development of atherosclerosis in Watanabe heritable hyperlipidaemic (WHHL) rabbits, 6-week-old animals were given a daily dose (1·5 ml/kg body weight) of fish oil (n 10) or olive oil (n 10) by oral administration for 16 weeks. Plasma cholesterol and triacylglycerols were measured once monthly, and their concentrations in lipoproteins, together with susceptibility of LDL to oxidation were measured in vitro at the termination of the experiment. Aortic atherosclerosis was quantified biochemically and microscopically. After 4 weeks of treatment, and throughout the study thereafter, blood lipids were significantly (P < 0·05) lower in the fish-oil group than in the olive-oil group (cholesterol: 17·0 v. 30·3 mmol/l, triacylglycerols 2·97 v. 6·25 mmol/l, at termination). In the fish-oil group cholesterol was significantly lower in intermediate-density lipoproteins (2·69 v. 6·76 mmol/l) and VLDL (3·36 v. 11·51 mmol/l). Triacylglycerol levels of intermediate-density lipoproteins and VLDL in the fish-oil group were also significantly lower when compared with the olive-oil group (0·54 v 1·36 mmol/l and 0·92 v. 2·87 mmol/l respectively). No group differences were recorded for LDL- and HDL-cholesterol or triacylglycerol levels. A significantly higher oxidation of LDL was recorded 1 h after exposure to CuSO4 in the fish-oil group when compared with the olive-oil group (0·465 v. 0·202, arbitrary units). The following indicators of atherosclerosis development were significantly lower in the fish-oil group than in the olive-oil group: the cholesterol content (mg/g tissue) in the ascending aorta (29·8 v.48·9), the intima:media value (4·81 v. 18·24) and the area of intima (0·10 v. 0·57 mm2) in the thoracic aorta. It was concluded that fish-oil treatment decreased blood lipids and the development of aortic atherosclerosis in WHHL rabbits when compared with olive-oil treatment. Copyright © The Nutrition Society 1998 WHHL rabbit nationallicence Fish oil nationallicence Olive oil nationallicence Atherosclerosis nationallicence Mortensen Alicja Danish Veterinary and Food Administration, Institute of Food Safety and Toxicology, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark Hansen Birgit Fischer Department of Pathology, Hvidovre Hospital, Kettegårdsvej 30, DK-2650 Hvidovre, Denmark Hansen Jørgen Fischer Department of Cardiology, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 København N, Denmark Frandsen Henrik Danish Veterinary and Food Administration, Institute of Food Safety and Toxicology, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark Bartnikowska Elzbieta Department of Human Nutrition, Warsaw Agriculture University, Nowoursynowska 166, Warsaw, Poland Andersen Peder S. Department of Biochemistry and Nutrition, Technical University of Denmark, DK-2800 Lyngby, Denmark Bertelsen Lone S. Department of Biochemistry and Nutrition, Technical University of Denmark, DK-2800 Lyngby, Denmark British Journal of Nutrition Cambridge University Press 80/6(1998-12), 565-573 0007-1145 80:6<565 1998 80 BJN https://doi.org/10.1017/S0007114598001664 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001664 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mortensen Alicja Danish Veterinary and Food Administration, Institute of Food Safety and Toxicology, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark NATIONALLICENCE 700 1- Hansen Birgit Fischer Department of Pathology, Hvidovre Hospital, Kettegårdsvej 30, DK-2650 Hvidovre, Denmark NATIONALLICENCE 700 1- Hansen Jørgen Fischer Department of Cardiology, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 København N, Denmark NATIONALLICENCE 700 1- Frandsen Henrik Danish Veterinary and Food Administration, Institute of Food Safety and Toxicology, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark NATIONALLICENCE 700 1- Bartnikowska Elzbieta Department of Human Nutrition, Warsaw Agriculture University, Nowoursynowska 166, Warsaw, Poland NATIONALLICENCE 700 1- Andersen Peder S. Department of Biochemistry and Nutrition, Technical University of Denmark, DK-2800 Lyngby, Denmark NATIONALLICENCE 700 1- Bertelsen Lone S. Department of Biochemistry and Nutrition, Technical University of Denmark, DK-2800 Lyngby, Denmark NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/6(1998-12), 565-573 0007-1145 80:6<565 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge