caa a22 4500 388062800 CHVBK 20180307125126.0 cr unu---uuuuu 161130e199802 xx s 000 0 eng 10.1079/BJN19980029 doi S0007114598000300 pii (NATIONALLICENCE)cambridge-10.1079/BJN19980029 Compensatory nutrition-directed mammary cell proliferation and lactation in rats [Elektronische Daten] The proper use of a time-dependent and controlled nutrition regimen during the hormone-sensitive growth phase before first parturition can significantly affect mammary growth and subsequent lactation performance. The objective of the present study was to determine if a compensatory nutrition regimen improves lactation performance by affecting proliferation and apoptosis of mammary epithelial cells. Forty female rats (7 weeks of age, average weight 148 g) were assigned to either (1) control, free access to diet or (2) stair-step compensatory nutrition regimen, an alternating 3-4-week schedule beginning with an energy-restricted diet (31·2% restriction) for 3 weeks, followed by the control diet for 4 weeks. Estimated milk yield was greater (P <0·05) on day 15 of lactation in the compensatory nutrition group than in the control group. Mammary cell proliferation values were 1·4- and 2·7-fold greater in mammary tissue from the compensatory group during pregnant and early lactating stages respectively, compared with those from the control group. Ornithine decarboxylase (EC 4.1.1.17)mRNA was 24% higher (P <0·05) in mammary tissues of rats from the compensatory nutrition group during pregnancy than in those from the control group. These results indicate that the compensatory nutrition regimen imposed during the peripubertal growth phase stimulated mammary epithelial cell proliferation and improved lactation performance. Copyright © The Nutrition Society 1998 Compensatory growth nationallicence Lactation nationallicence Mammary tissue nationallicence Kim S. H. Department of Oncology/Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA Moon Y. S. Department of Nutritional Sciences, University of California, Berkeley, CA 94720, USA Keller W. L. Department of Animal and Range Sciences, North Dakota State University, Fargo, ND 58105, USA Park C. S. Department of Animal and Range Sciences, North Dakota State University, Fargo, ND 58105, USA British Journal of Nutrition Cambridge University Press 79/2(1998-02), 177-183 0007-1145 79:2<177 1998 79 BJN https://doi.org/10.1079/BJN19980029 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19980029 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim S. H. Department of Oncology/Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA NATIONALLICENCE 700 1- Moon Y. S. Department of Nutritional Sciences, University of California, Berkeley, CA 94720, USA NATIONALLICENCE 700 1- Keller W. L. Department of Animal and Range Sciences, North Dakota State University, Fargo, ND 58105, USA NATIONALLICENCE 700 1- Park C. S. Department of Animal and Range Sciences, North Dakota State University, Fargo, ND 58105, USA NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 79/2(1998-02), 177-183 0007-1145 79:2<177 1998 79 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge