caa a22 4500 388062878 CHVBK 20180307125126.0 cr unu---uuuuu 161130e199802 xx s 000 0 eng 10.1079/BJN19980024 doi S0007114598000257 pii (NATIONALLICENCE)cambridge-10.1079/BJN19980024 Apolipoprotein E genotype modulates the effect of black tea drinking on blood lipids and blood coagulation factors: a pilot study [Elektronische Daten] Apolipoprotein E (ApoE) genotype was determined in sixty-five subjects who had taken part in a 4-week randomized crossover trial to compare the effect of six mugs of black tea per day v. placebo on blood lipids and blood coagulation factors. Four ApoE genotype variants (seven E2/E3, forty-five E3/E3, twelve E3/E4 and one E4/E4) were found. ApoE allele frequency was within the range typical for Caucasian populations (ApoE-E2 5·4 %; ApoE-E3 83·8 %; ApoE-E4 10·8 %). Individuals bearing at least one E4 allele had substantially higher levels of serum total cholesterol, LDL cholesterol and triacylglycerols. Mean plasminogen activator inhibitor (PAI-1) activity was higher in ApoE-E4 allele-bearing individuals (E3/E4 + E4/E4, 11·89 (SE 1·27) U/ml; E3/E3, 9·19 (SE 0·80) U/ml; E2/E3, 7·21 (SE 1·04) U/ml, P values of E4-group v. E3 and E2 being respectively 0·093 and 0·030). These unexpected findings imply that elevated PAI-1 activity may be a hitherto unrecognized additional factor involved in the increased cardiovascular disease risk associated with apoE-E4 allele. The interactions between tea drinking and genotype were also examined. In the E3/E3 homozygotes, HDL-cholesterol was significantly reduced in the tea period (mean placebo 1·54 mmol/l v. mean tea 1·50 mmol/l, P = 0·027). In the E2/E3 group, triacylglycerol concentration was significantly reduced (mean placebo 1·18 mmol/l v. mean tea 1·09 mmol/l, P = 0·039). Tea also caused a significant decrease of PAI-1 activity in the subjects with E2/E3 genotype (mean placebo 7·21 U/ml v. mean tea 5.88 U/ml, P = 0·007). In the other two genotype groups, there was no significant effect of tea. The results indicate that tea drinking has a beneficial effect on some cardiovascular disease risk-associated factors, especially in E2 allele-bearing individuals. Dietary intervention may be particularly effective in population groups with certain genetic characteristics. Copyright © The Nutrition Society 1998 Apolipoproteins nationallicence Cardiovascular disease nationallicence Genotype nationallicence Dietary intervention nationallicence Tea nationallicence Loktionov Alexandre Medical Research Council, Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, UK Bingham Sheila A. Medical Research Council, Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, UK Vorster Hester Department of Nutrition, Potchefstroom University for Christian Higher Education, Potchefstroom, South Africa Jerling Johann C. Department of Nutrition, Potchefstroom University for Christian Higher Education, Potchefstroom, South Africa Runswick Shirley A. Medical Research Council, Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, UK Cummings John H. Medical Research Council, Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, UK British Journal of Nutrition Cambridge University Press 79/2(1998-02), 133-139 0007-1145 79:2<133 1998 79 BJN https://doi.org/10.1079/BJN19980024 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19980024 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Loktionov Alexandre Medical Research Council, Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, UK NATIONALLICENCE 700 1- Bingham Sheila A. Medical Research Council, Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, UK NATIONALLICENCE 700 1- Vorster Hester Department of Nutrition, Potchefstroom University for Christian Higher Education, Potchefstroom, South Africa NATIONALLICENCE 700 1- Jerling Johann C. Department of Nutrition, Potchefstroom University for Christian Higher Education, Potchefstroom, South Africa NATIONALLICENCE 700 1- Runswick Shirley A. Medical Research Council, Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, UK NATIONALLICENCE 700 1- Cummings John H. Medical Research Council, Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, UK NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 79/2(1998-02), 133-139 0007-1145 79:2<133 1998 79 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge