caa a22 4500 388062932 CHVBK 20180307125126.0 cr unu---uuuuu 161130e199811 xx s 000 0 eng 10.1017/S0007114598001512 doi S0007114598001512 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001512 Lutein ester in serum after lutein supplementation in human subjects [Elektronische Daten] Lutein, one of the major carotenoids present in serum, is also widely consumed by most populations. For the purpose of testing the potential health benefits of several carotenoids, lutein was supplied as part of an intervention trial to test whether the consumption of these food constituents reduces oxidative damage to human tissue components. Lutein from a natural source (15 mg/d as mixed ester forms) was supplied for 4 months to eighteen non-smoking, apparently healthy volunteers (nine men, nine women) aged 25-45 years. The serum carotenoid profile was analysed at baseline and monthly thereafter. On average, lutein concentrations increased 5-fold after the first month of supplementation (mean 1·34 (range 0·6-3·34) μmol/l). On reviewing the results, in those volunteers whose lutein levels surpassed 1·05 μmol/l (fourteeen of seventeen), we tentatively identified lutein monopalmitate along with another unidentified ester (possibly from a monoketocarotenoid) in serum. Lutein levels returned to baseline values and ester forms were not present 3 months after supplementation was discontinued. Their concentrations did not correlate with, and represented less than 3% of, lutein levels achieved in serum. They were observed before development of, and despite the presence of, carotenodermia. To our knowledge, this is the first time xanthophyll esters have been described in human serum. In view of the fact that xanthophyll esters have not been previously reported in serum and chylomicrons, it seems unlikely that these ester forms would be a reflection of the contents of the capsule. They may indicate a ‘ceiling effect' on or saturation of the transport capacity for xanthophylls, and may have been re-esterified in vivo because of the unusual dietary conditions. The determination of the physiological importance of this finding will require further investigation, although neither haematological nor biochemical changes were detected. Copyright © The Nutrition Society 1998 Lutein nationallicence Carotenoids nationallicence Antioxidants nationallicence Granado Fernando Servicio de Nutrición, Clínica Puerta de Hierro, Madrid, Spain Olmedilla Begoña Servicio de Nutrición, Clínica Puerta de Hierro, Madrid, Spain Gil-Martínez Enrique Servicio de Nutrición, Clínica Puerta de Hierro, Madrid, Spain Blanco Inmaculada Servicio de Nutrición, Clínica Puerta de Hierro, Madrid, Spain British Journal of Nutrition Cambridge University Press 80/5(1998-11), 445-449 0007-1145 80:5<445 1998 80 BJN https://doi.org/10.1017/S0007114598001512 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001512 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Granado Fernando Servicio de Nutrición, Clínica Puerta de Hierro, Madrid, Spain NATIONALLICENCE 700 1- Olmedilla Begoña Servicio de Nutrición, Clínica Puerta de Hierro, Madrid, Spain NATIONALLICENCE 700 1- Gil-Martínez Enrique Servicio de Nutrición, Clínica Puerta de Hierro, Madrid, Spain NATIONALLICENCE 700 1- Blanco Inmaculada Servicio de Nutrición, Clínica Puerta de Hierro, Madrid, Spain NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/5(1998-11), 445-449 0007-1145 80:5<445 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge