caa a22 4500 388062940 CHVBK 20180307125126.0 cr unu---uuuuu 161130e199811 xx s 000 0 eng 10.1017/S0007114598001561 doi S0007114598001561 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001561 The effects of maternal intake and gestational age on materno-fetal transport of vitamin C in the guinea-pig [Elektronische Daten] The effects of maternal intake and gestational age on materno-fetal transport of vitamin C were investigated in female Dunkin-Hartley guinea-pigs. Twenty-four time-mated dams were fed on either a moderate-vitamin C (group A) or a high-vitamin C (group B) diet, throughout pregnancy. At days 49, 63 and 66 of gestation, and at term, three animals from each group were killed and fetuses removed by hysterectomy. Plasma, liver, kidney, lungs, heart, placenta and amniotic fluid were collected from dams and fetuses and subsequently analysed for vitamin C. Fetal plasma and amniotic fluid concentrations showed negative associations with gestational age for both dietary groups, independent of an effect of dam (P < 0.001). A similar, though not significant, effect of gestational age was observed on placental vitamin C and group A fetal tissue concentrations. Fetal plasma, placental and amniotic fluid vitamin C concentrations were significantly higher in group B than group A (P < 0.001), suggesting the influence of maternal diet. Although the level of maternal vitamin C intake can influence the circulating concentration in the fetus, there is a decrease associated with increasing gestational age, independent of the maternal diet. The gestational age-dependent change in the fetal accumulation of vitamin C may reflect changes in the rate of placental transfer. Copyright © The Nutrition Society 1998 Vitamin C nationallicence Materno-fetal transport nationallicence Guinea-pig nationallicence Das S. Division of Child Health, University of Sheffield, Sheffield S10 2TH, UK Powers H. J. Division of Child Health, University of Sheffield, Sheffield S10 2TH, UK British Journal of Nutrition Cambridge University Press 80/5(1998-11), 485-491 0007-1145 80:5<485 1998 80 BJN https://doi.org/10.1017/S0007114598001561 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001561 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Das S. Division of Child Health, University of Sheffield, Sheffield S10 2TH, UK NATIONALLICENCE 700 1- Powers H. J. Division of Child Health, University of Sheffield, Sheffield S10 2TH, UK NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/5(1998-11), 485-491 0007-1145 80:5<485 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge