caa a22 4500 388063017 CHVBK 20180307125126.0 cr unu---uuuuu 161130e199811 xx s 000 0 eng 10.1017/S0007114598001470 doi S0007114598001470 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001470 The effect of acute carbohydrate load on the monophasic or biphasic nature of the postprandial lipaemic response to acute fat ingestion in human subjects [Elektronische Daten] Previous studies in this laboratory have elicited a monophasic response in postprandial plasma triacylglycerol (TAG) level with fat intakes of 0.5 g fat/kg body weight accompanied by about 17 g carbohydrate as lactose. Recent studies involving the same level of fat with a higher level of carbohydrate, 136 g of which 60 g was sucrose, appeared to elicit a biphasic response. The present study compared these two test meals and showed a significant meal × time interaction for plasma total TAG (P = 0.0228) reflecting a monophasic response with the lower-carbohydrate test meal. The higher-carbohydrate meal induced significantly higher insulin and glucose-dependent insulinotropic polypeptide responses (P = 0.0009 and P = 0.0041 respectively). A significant meal × time interaction was seen for plasma non-esterified fatty acids (P = 0.0437). The biphasic plasma TAG response seen with the high-carbohydrate meal largely reflected the TAG-rich lipoprotein (TRL) or chylomicron fraction, which would tend to suggest a biphasic pattern of absorption. This was borne out by TRL-TAG fatty acid compositions. Both peaks in the biphasic response showed active incorporation of the main dietary fatty acids, 18:1n−9, 18:2n−6 and 18:3n−3 into TRL-TAG. These results indicate that under the specific test-meal conditions used in the present study, a biphasic pattern of fat absorption was seen. Copyright © The Nutrition Society 1998 Postprandial metabolism nationallicence Carbohydrate nationallicence Fat nationallicence Shishehbor Farideh Unit of Nutrition and Dietetics, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Republic of Ireland Roche Helen M. Unit of Nutrition and Dietetics, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Republic of Ireland Gibney Michael J. Unit of Nutrition and Dietetics, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Republic of Ireland British Journal of Nutrition Cambridge University Press 80/5(1998-11), 411-418 0007-1145 80:5<411 1998 80 BJN https://doi.org/10.1017/S0007114598001470 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001470 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shishehbor Farideh Unit of Nutrition and Dietetics, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Republic of Ireland NATIONALLICENCE 700 1- Roche Helen M. Unit of Nutrition and Dietetics, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Republic of Ireland NATIONALLICENCE 700 1- Gibney Michael J. Unit of Nutrition and Dietetics, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Republic of Ireland NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/5(1998-11), 411-418 0007-1145 80:5<411 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge