caa a22 4500 388063106 CHVBK 20180307125126.0 cr unu---uuuuu 161130e199809 xx s 000 0 eng 10.1017/S0007114598001342 doi S0007114598001342 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001342 Protein deficiency during pregnancy and lactation impairs glucose-induced insulin secretion but increases the sensitivity to insulin in weaned rats [Elektronische Daten] We studied glucose homeostasis in rat pups from dams fed on a normal-protein (170 g/kg) (NP) diet or a diet containing 60 g protein/kg (LP) during fetal life and the suckling period. At birth, total serum protein, serum albumin and serum insulin levels were similar in both groups. However, body weight and serum glucose levels in LP rats were lower than those in NP rats. At the end of the suckling period (28 d of age), total serum protein, serum albumin and serum insulin were significantly lower and the liver glycogen and serum free fatty acid levels were significantly higher in LP rats compared with NP rats. Although the fasting serum glucose level was similar in both groups, the area under the blood glucose concentration curve after a glucose load was higher for NP rats (859 (sem 58) mmol/l per 120 min for NP rats v. 607 (sem 52) mmol/l per 120 min for LP rats; P < 0.005). The mean post-glucose increase in insulin was higher for NP rats (30 (sem 4.7) nmol/l per 120 min for NP rats v. 17 (sem 3.9) nmol/l per 120 min for LP rats; P < 0.05). The glucose disappearance rate for NP rats (0.7 (sem 0.1) %/min) was lower than that for LP rats (1.6 (sem 0.2)%/min; P < 0.001). Insulin secretion from isolated islets (1 h incubation) in response to 16.7mmol glucose/l was augmented 14-fold in NP rats but only 2.6-fold in LP rats compared with the respective basal secretion (2.8 mmol/l; P < 0.001). These results indicate that in vivo as well as in vitro insulin secretion in pups from dams maintained on a LP diet is reduced. This defect may be counteracted by an increase in the sensitivity of target tissues to insulin. Copyright © The Nutrition Society 1998 Protein malnutrition nationallicence Insulin nationallicence Glucose homeostasis nationallicence Latorraca Márcia Q. Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil Carneiro Everardo M. Departamento de Educação Física, Instituto de Biociências, Universidade Estadual Paulista, Rio Claro, SP, Brazil Boschero Antonio C. Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil Mello Maria A. R. Departamento de Educação Física, Instituto de Biociências, Universidade Estadual Paulista, Rio Claro, SP, Brazil British Journal of Nutrition Cambridge University Press 80/3(1998-09), 291-297 0007-1145 80:3<291 1998 80 BJN https://doi.org/10.1017/S0007114598001342 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001342 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Latorraca Márcia Q. Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil NATIONALLICENCE 700 1- Carneiro Everardo M. Departamento de Educação Física, Instituto de Biociências, Universidade Estadual Paulista, Rio Claro, SP, Brazil NATIONALLICENCE 700 1- Boschero Antonio C. Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil NATIONALLICENCE 700 1- Mello Maria A. R. Departamento de Educação Física, Instituto de Biociências, Universidade Estadual Paulista, Rio Claro, SP, Brazil NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/3(1998-09), 291-297 0007-1145 80:3<291 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge