caa a22 4500 388063149 CHVBK 20180307125126.0 cr unu---uuuuu 161130e199809 xx s 000 0 eng 10.1017/S0007114598001299 doi S0007114598001299 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001299 Effect on plasma lipids and lipoproteins of replacing partially hydrogenated fish oil with vegetable fat in margarine [Elektronische Daten] We have compared the effects on lipoproteins and haemostatic variables of two hard margarines with similar functional properties, one traditional margarine containing partially hydrogenated fish oil (PHFO), and one experimental margarine based on vegetable oil (VO). Both were all-purpose cooking margarines with nearly identical functional properties. Trans fatty acids from PHFO in the traditional margarine were replaced mostly by saturated, monounsaturated and trans fatty acids of vegetable origin in the new formulation. Both test margarines contained approximately the same amount of cis polyunsaturated fatty acids. Sixteen female normolipidaemic students consumed each diet with the two test margarines for 14 d in random order (crossover design). The amount of fat was 31 % energy in the PHFO diet and 32 % energy in the VO diet. The test margarines provided approximately 26% energy in both diets. In the PHFO diet 7.8 % of the energy was derived from trans fatty acids and 9.2 % from saturated fatty acids (12:0, 14:0 and 16:0) while in the VO diet, 1.1 % energy was derived from trans fatty acids and 13.3% from saturated fatty acids (12:0, 14:0 and 16:0). The natural content of cholesterol in PHFO was deliberately not balanced by addition of cholesterol to the VO diet, thus the PHFO diet contained 215 mg and the VO diet 86 mg cholesterol per 8.5 MJ. LDL-cholesterol concentration was 19 % higher in subjects on the PHFO diet compared with the VO diet (P < 0.01). The ratio LDL-cholesterol:HDL-cholesterol was 12.6 % higher in subjects on the PHFO diet compared with the VO diet (P < 0.01). The level of apolipoprotein (apo)A-I was 6 % lower in subjects on the PHFO diet compared with the VO diet (P < 0.01). The ratio apoB:apoA-I was 10.4 % higher in subjects on the PHFO diet than on the VO diet (P < 0.01). There were no significant differences in total cholesterol, HDL-cholesterol, triacylglycerols, apoB, lipoprotein(a) and haemostatic variables between the diets. Our results demonstrate that PHFO, with its unfavourable effects on plasma lipids, can be replaced by vegetable oils in margarine without appreciable loss of functional properties but with significant improvement in the effects on plasma lipoproteins. Copyright © The Nutrition Society 1998 Plasma lipoproteins nationallicence Fish oil nationallicence Hydrogenated fat nationallicence Trans fatty acids nationallicence Müller Hanne Akershus College, 1340 Bekkestua, Norway Jordal Odd Institute for Nutrition Research, University of Oslo, PO Box 1046 Blindern, 0316 Oslo, Norway Seljeflot Ingebjørg Clinical Chemistry Department Ullevaal University Hospital, 0407 Oslo, Norway Kierulf Peter Clinical Chemistry Department Ullevaal University Hospital, 0407 Oslo, Norway Kirkhus Bente Mills DA, 0506 Oslo, Norway Ledsaak Oddlaug Akershus College, 1340 Bekkestua, Norway Pedersen Jan I. Akershus College, 1340 Bekkestua, Norway British Journal of Nutrition Cambridge University Press 80/3(1998-09), 243-251 0007-1145 80:3<243 1998 80 BJN https://doi.org/10.1017/S0007114598001299 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001299 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Müller Hanne Akershus College, 1340 Bekkestua, Norway NATIONALLICENCE 700 1- Jordal Odd Institute for Nutrition Research, University of Oslo, PO Box 1046 Blindern, 0316 Oslo, Norway NATIONALLICENCE 700 1- Seljeflot Ingebjørg Clinical Chemistry Department Ullevaal University Hospital, 0407 Oslo, Norway NATIONALLICENCE 700 1- Kierulf Peter Clinical Chemistry Department Ullevaal University Hospital, 0407 Oslo, Norway NATIONALLICENCE 700 1- Kirkhus Bente Mills DA, 0506 Oslo, Norway NATIONALLICENCE 700 1- Ledsaak Oddlaug Akershus College, 1340 Bekkestua, Norway NATIONALLICENCE 700 1- Pedersen Jan I. Akershus College, 1340 Bekkestua, Norway NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/3(1998-09), 243-251 0007-1145 80:3<243 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge