caa a22 4500 388063173 CHVBK 20180307125127.0 cr unu---uuuuu 161130e199807 xx s 000 0 eng 10.1017/S0007114598001767 doi S0007114598001767 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001767 Infants in Trinidad excrete more 5-L-oxoproline (L-pyroglutamic acid) in urine than infants in England: an environmental not ethnic difference [Elektronische Daten] The demand for glycine to satisfy normal growth during early life is considerable and most has to be made endogenously. The extent to which adequate glycine is available can be assessed by measuring the urinary excretion of 5-L-oxoproline. The excretion of 5-L-oxoproline at 6 weeks of age for infants in Trinidad of African, Indian or mixed parentage (398 μmol/mmol creatinine) was significantly greater than for infants born in England of Caucasian parentage (194 μmol/mmol creatinine). There was no relationship between 5-L-oxoproline excretion and either sex or pattern of feeding. There were significant inverse relationships between 5-L-oxoproline/creatinine and birth weight, and head circumference either at birth or 6 weeks of age, suggesting that limited availability of glycine is associated with poorer growth before and after birth. For a group of infants born in England of Indian parentage, excretion of 5-L-oxoproline (155 μmol/mmol creatinine) was not different to infants of Caucasian parentage, but significantly less than infants born in Trinidad. The demonstration that 5-L-oxoproline/creatinine was similar in infants born in England, regardless of parentage, shows that the differences between England and Trinidad are related to environment and are unlikely to be accounted for by genetic differences or ethnicity. Copyright © The Nutrition Society 1998 5-L-Oxoproline nationallicence Glycine nationallicence Growth nationallicence Lenton C. Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK Ali Z. Mount Hope Women's Hospital, Trinidad and Tobago, West Indies Persaud C. Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK Jackson A.A. Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK British Journal of Nutrition Cambridge University Press 80/1(1998-07), 51-55 0007-1145 80:1<51 1998 80 BJN https://doi.org/10.1017/S0007114598001767 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001767 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lenton C. Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK NATIONALLICENCE 700 1- Ali Z. Mount Hope Women's Hospital, Trinidad and Tobago, West Indies NATIONALLICENCE 700 1- Persaud C. Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK NATIONALLICENCE 700 1- Jackson A.A. Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/1(1998-07), 51-55 0007-1145 80:1<51 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge