caa a22 4500 38806319X CHVBK 20180307125127.0 cr unu---uuuuu 161130e199807 xx s 000 0 eng 10.1017/S0007114598001792 doi S0007114598001792 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001792 Vitamin A status does not influence neopterin production during illness or health in South African children [Elektronische Daten] Excessive interferon-gamma (IFN-γ) production appears to be a primary immunological lesion in vitamin A-deficient experimental animals but comparable data from humans is lacking. We investigated IFN-γ production in South African children by measurement of urinary excretion of neopterin, a product of IFN-γ-activated monocytes or macrophages. Preschool children were examined during an acute inflammatory illness resulting from accidental ingestion of kerosene and they and a neighbourhood control child were examined 3 months later when well. Vitamin A status was assessed by the modified relative dose response (MRDR) test at 3 months and serum retinol and acute phase proteins were measured at both time points. Urinary neopterin was measured for forty cases in hospital, forty-six cases after recovery, and forty-one controls. Significantly increased neopterin excretion was seen following kerosene ingestion and in association with raised serum acute phase protein concentrations. There was no relationship between neopterin excretion at either time point and vitamin A status as assessed by MRDR test. Urinary neopterin was negatively correlated with serum retinol but no significant relationship was observed when acute phase protein concentrations were included in a multiple regression, suggesting the correlation was secondary to illness-induced changes in serum retinol. The results indicate that, contrary to what is observed in rodents under experimental conditions, poor vitamin A status is not associated with altered regulation of IFN-γ production in children. Copyright © The Nutrition Society 1998 Vitamin A nationallicence Neopterin nationallicence Interferon nationallicence Childhood nationallicence Filteau Suzanne M. Centre for International Child Health, Institute of Child Health, London WC1N 1EH, UK Raynes John G. Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, London WC1E 4HT, UK Simmank Karin Department of Community Pediatrics, Baragwanath Hospital, University of Witwatersrand, Soweto, PO Bertsham 2013, South Africa Wagstaff Lucy A. Department of Community Pediatrics, Baragwanath Hospital, University of Witwatersrand, Soweto, PO Bertsham 2013, South Africa British Journal of Nutrition Cambridge University Press 80/1(1998-07), 75-79 0007-1145 80:1<75 1998 80 BJN https://doi.org/10.1017/S0007114598001792 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001792 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Filteau Suzanne M. Centre for International Child Health, Institute of Child Health, London WC1N 1EH, UK NATIONALLICENCE 700 1- Raynes John G. Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, London WC1E 4HT, UK NATIONALLICENCE 700 1- Simmank Karin Department of Community Pediatrics, Baragwanath Hospital, University of Witwatersrand, Soweto, PO Bertsham 2013, South Africa NATIONALLICENCE 700 1- Wagstaff Lucy A. Department of Community Pediatrics, Baragwanath Hospital, University of Witwatersrand, Soweto, PO Bertsham 2013, South Africa NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/1(1998-07), 75-79 0007-1145 80:1<75 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge