caa a22 4500 388063270 CHVBK 20180307125127.0 cr unu---uuuuu 161130e199807 xx s 000 0 eng 10.1017/S0007114598001743 doi S0007114598001743 pii (NATIONALLICENCE)cambridge-10.1017/S0007114598001743 Development of macronutrient composition of very preterm human milk [Elektronische Daten] The effects of gestational age at delivery (GA), postnatal age (PNA) and post-menstrual age (PMA=PNA+GA, an indicator of autonomous developmental processes not affected by the moment of birth) on macronutrient composition of very preterm milk were studied. Total N, fat, lactose and carbohydrate concentrations, energy density and 24 h volume were determined in 282 24 h milk samples collected at weekly intervals (days 7-55 of lactation) from seventy-nine women delivering their babies between 25 and 29 weeks of gestation. GA related differences were found for carbohydrate concentration only: carbohydrate concentration was lower with increasing GA. PNA was related to a decrease in total N and an increase in lactose concentration. PMA was not related to milk composition. Our data indicate that PNA strongly influences the development of the composition of very preterm human milk, while GA affects carbohydrate content with a negligible effect on the nutritional value of the milk. We conclude that in accordance with current opinion in paediatrics, human milk is the best source of nutrients even for very preterm (< 30 weeks GA) infants. Copyright © The Nutrition Society 1998 Human milk nationallicence Preterm infant nationallicence Development nationallicence Maas Yolande G. H. Department of Neonatology, Academic Medical Center, University of Amsterdam, Emma Childrens' Hospital, PO Box 22700, 1100 DE Amsterdam, The Netherlands Gerritsen Jeanet Department of Neonatology, Academic Medical Center, University of Amsterdam, Emma Childrens' Hospital, PO Box 22700, 1100 DE Amsterdam, The Netherlands Hart Augustinus A. M. Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Emma Childrens' Hospital, PO Box 22700, 1100 DE Amsterdam, The Netherlands Hadders-Algra Mijna Department of Medical Physiology, University of Groningen, Bloemsingel 10, 9712 KZ Groningen, The Netherlands Ruijter Jan M. The Netherlands Ophthalmic Research Institute and Laboratory of Medical Physics, PO Box 12141, 1100 AC Amsterdam, The Netherlands Tamminga Pieter Department of Neonatology, Academic Medical Center, University of Amsterdam, Emma Childrens' Hospital, PO Box 22700, 1100 DE Amsterdam, The Netherlands Mirmiran Majid Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands Spekreijse Henk The Netherlands Ophthalmic Research Institute and Laboratory of Medical Physics, PO Box 12141, 1100 AC Amsterdam, The Netherlands British Journal of Nutrition Cambridge University Press 80/1(1998-07), 35-40 0007-1145 80:1<35 1998 80 BJN https://doi.org/10.1017/S0007114598001743 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0007114598001743 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maas Yolande G. H. Department of Neonatology, Academic Medical Center, University of Amsterdam, Emma Childrens' Hospital, PO Box 22700, 1100 DE Amsterdam, The Netherlands NATIONALLICENCE 700 1- Gerritsen Jeanet Department of Neonatology, Academic Medical Center, University of Amsterdam, Emma Childrens' Hospital, PO Box 22700, 1100 DE Amsterdam, The Netherlands NATIONALLICENCE 700 1- Hart Augustinus A. M. Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Emma Childrens' Hospital, PO Box 22700, 1100 DE Amsterdam, The Netherlands NATIONALLICENCE 700 1- Hadders-Algra Mijna Department of Medical Physiology, University of Groningen, Bloemsingel 10, 9712 KZ Groningen, The Netherlands NATIONALLICENCE 700 1- Ruijter Jan M. The Netherlands Ophthalmic Research Institute and Laboratory of Medical Physics, PO Box 12141, 1100 AC Amsterdam, The Netherlands NATIONALLICENCE 700 1- Tamminga Pieter Department of Neonatology, Academic Medical Center, University of Amsterdam, Emma Childrens' Hospital, PO Box 22700, 1100 DE Amsterdam, The Netherlands NATIONALLICENCE 700 1- Mirmiran Majid Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands NATIONALLICENCE 700 1- Spekreijse Henk The Netherlands Ophthalmic Research Institute and Laboratory of Medical Physics, PO Box 12141, 1100 AC Amsterdam, The Netherlands NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/1(1998-07), 35-40 0007-1145 80:1<35 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge