caa a22 4500 388063343 CHVBK 20180307125127.0 cr unu---uuuuu 161130e199808 xx s 000 0 eng 10.1079/BJN19980108 doi S0007114598001226 pii (NATIONALLICENCE)cambridge-10.1079/BJN19980108 Functional food science and gastrointestinal physiology and function [Elektronische Daten] The gut is an obvious target for the development of functional foods, acting as it does as the interface between diet and the metabolic events which sustain life. The key processes in digestive physiology which can be regulated by modifying diet are satiety, the rate and extent of macronutrient breakdown and absorption from the small bowel, sterol metabolism, the colonic microflora, fermentation, mucosal function and bowel habit, and the gut immune system. The intestinal microflora is the main focus of many current functional foods. Probiotics are foods which contain live bacteria which are beneficial to health whilst prebiotics, such as certain non-digestible oligosaccharides which selectively stimulate the growth of bifidobacteria in the colon, are already on the market. Their claimed benefits are to alleviate lactose maldigestion, increase resistance to invasion by pathogenic species of bacteria in the gut, stimulate the immune system and possibly protect against cancer. There are very few reports of well-designed human intervention studies with prebiotics as yet. Certain probiotic species have been shown to shorten the duration of rotavirus diarrhoea in children but much more work is needed on the mechanism of immunomodulation and of competitive exclusion and microflora modification. The develop-ment of functional foods for the gut is in its infancy and will be successful only if more fundamental research is done on digestive physiology, the gut microflora, immune system and mucosal function. Copyright © The Nutrition Society 1998 Gastrointestinal function nationallicence Microflora nationallicence Immune system nationallicence Salminen S. Department of Biochemistry and Food Chemistry, University of Turku, SF-20500 Turku, Finland Bouley C. Groupe Danone, 15, Av. Galilée, F-92350 Le Plessis-Robinson, France Boutron M.-C U290 INSERM, Hôspital St Lazare, 107, rue du Faubourg Saint-Denis, F-75010 Paris, France Cummings J. H. Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, UK Franck A. Raffinerie Tirlernontoise - ORAFTI, Aandorenstraat I, B-3300 Tienen, Belgium Gibson G. R. Institute of Food Research, Reading Laboratory, Earley Gate, Reading RG6 6BZ, UK Isolauri E. University of Tampere Medical School, PO Box 607, SF-33101 Tampere, Finland Moreau M.-C INRA - Unité d'Ecologie et de Physiologie du Systèrne Digestif, Bâitirnent 440 R-2, Domaine de Vilvert, F- 78352 Jouy-en-Josas Cedex, France Roberfroid M. UCL, Ecole de Pharmacie, Tour Van Helmont, Avenue E. Mounier, 73, B-1200 Brussels, Belgium Rowland I. University of Ulster, Coleraine BT52 ISA, UK British Journal of Nutrition Cambridge University Press 80/S1(1998-08), S147-S171 0007-1145 80:S1<S147 1998 80 BJN https://doi.org/10.1079/BJN19980108 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19980108 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Salminen S. Department of Biochemistry and Food Chemistry, University of Turku, SF-20500 Turku, Finland NATIONALLICENCE 700 1- Bouley C. Groupe Danone, 15, Av. Galilée, F-92350 Le Plessis-Robinson, France NATIONALLICENCE 700 1- Boutron M.-C U290 INSERM, Hôspital St Lazare, 107, rue du Faubourg Saint-Denis, F-75010 Paris, France NATIONALLICENCE 700 1- Cummings J. H. Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, UK NATIONALLICENCE 700 1- Franck A. Raffinerie Tirlernontoise - ORAFTI, Aandorenstraat I, B-3300 Tienen, Belgium NATIONALLICENCE 700 1- Gibson G. R. Institute of Food Research, Reading Laboratory, Earley Gate, Reading RG6 6BZ, UK NATIONALLICENCE 700 1- Isolauri E. University of Tampere Medical School, PO Box 607, SF-33101 Tampere, Finland NATIONALLICENCE 700 1- Moreau M.-C INRA - Unité d'Ecologie et de Physiologie du Systèrne Digestif, Bâitirnent 440 R-2, Domaine de Vilvert, F- 78352 Jouy-en-Josas Cedex, France NATIONALLICENCE 700 1- Roberfroid M. UCL, Ecole de Pharmacie, Tour Van Helmont, Avenue E. Mounier, 73, B-1200 Brussels, Belgium NATIONALLICENCE 700 1- Rowland I. University of Ulster, Coleraine BT52 ISA, UK NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 80/S1(1998-08), S147-S171 0007-1145 80:S1<S147 1998 80 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge