caa a22 4500 388063564 CHVBK 20180307125128.0 cr unu---uuuuu 161130e199801 xx s 000 0 eng 10.1079/BJN19980006 doi S0007114598000075 pii (NATIONALLICENCE)cambridge-10.1079/BJN19980006 A comparison of iron absorption in adults and infants consuming identical infant formulas [Elektronische Daten] Fe absorption was estimated in adults and infants from the erythrocyte incorporation of Fe isotopes added to infant formula. Fe absorption was measured in adults using radioisotopes, and in infants with a stable-isotope technique. In adults, the geometric mean Fe absorption from a ready-to-feed soya formula with its native phytic acid content was 2·4%. This increased to 6·0% (P < 0·05) after almost complete dephytinization. In infants, mean Fe absorption values were 3·9 and 8·7% respectively from the same products (P <0·05). In adults, mean Fe absorption from a spray-dried soya formula containing 110mg ascorbic acid/I was 4·1%, increasing to 5·3% (P < 0·05) when ascorbic acid was doubled to 220 mg/l. In infants, mean Fe absorption values were 5·7 and 9·5% (P < 0·05) from the same products. Mean Fe absorption from a milk-based formula was 6·5% in adults compared with 6·7% in infants. All meals in the adult and infant studies were fed using an identical meal size of 217g. Increasing the meal size threefold in adults did not change fractional Fe absorption. Mean Fe absorption values for each meal were lower in adults than in infants, but the relative inhibitory effect of phytic acid and the enhancing effect of ascorbic acid were similar. We conclude that Fe absorption studies in adults can be used to assess the influence of enhancers and inhibitors of Fe absorption in infant formulas fed to infants. Further studies, however, are required to extend these findings to weaning foods and complete meals. Copyright © The Nutrition Society 1998 Iron nationallicence Formula intake nationallicence Infants nationallicence Phytate nationallicence Ascorbic acid nationallicence Hurrell Richard F. Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zürich, PO Box 474, CH-8803 Rüschlikon, Switzerland Davidsson Lena Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zürich, PO Box 474, CH-8803 Rüschlikon, Switzerland Reddy Manju Kansas University Medical Center, Kansas City, KS 66103, USA Kastenmayer Peter Nestlé Research Centre, PO Box 44, CH-1000 Lausanne 26, Switzerland Cook James D. Kansas University Medical Center, Kansas City, KS 66103, USA British Journal of Nutrition Cambridge University Press 79/1(1998-01), 31-36 0007-1145 79:1<31 1998 79 BJN https://doi.org/10.1079/BJN19980006 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19980006 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hurrell Richard F. Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zürich, PO Box 474, CH-8803 Rüschlikon, Switzerland NATIONALLICENCE 700 1- Davidsson Lena Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zürich, PO Box 474, CH-8803 Rüschlikon, Switzerland NATIONALLICENCE 700 1- Reddy Manju Kansas University Medical Center, Kansas City, KS 66103, USA NATIONALLICENCE 700 1- Kastenmayer Peter Nestlé Research Centre, PO Box 44, CH-1000 Lausanne 26, Switzerland NATIONALLICENCE 700 1- Cook James D. Kansas University Medical Center, Kansas City, KS 66103, USA NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 79/1(1998-01), 31-36 0007-1145 79:1<31 1998 79 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge