caa a22 4500 388063580 CHVBK 20180307125128.0 cr unu---uuuuu 161130e199801 xx s 000 0 eng 10.1079/BJN19980010 doi S0007114598000117 pii (NATIONALLICENCE)cambridge-10.1079/BJN19980010 Alternative models for analyses of liver and mammary transorgan metabolite extraction data [Elektronische Daten] Alternative models for analyses of liver and mammary transorgan data were formulated and fitted to liver and mammary data sets respectively. The models considered metabolite inputs to and effluxes from an extracellular pool. In general, fits were greatly improved over previous efforts using other models (Miller et al. 1991a; Hanigan et al. 1992; Wray-Cahen et al. 1997). Errors of prediction were generally less than 15% for liver and less than 20% for mammary glands. With the possible exception of glutamine for the udder, all metabolites exhibited linear responses to extracellular concentrations within the observed ranges of inputs. However, prediction biases were evident for β-hydroxybutyrate, acetate, and propionate by liver and for arginine, histidine, citrulline and glycerol by mammary tissue. These biases were hypothesized to be caused by the existence of additional regulatory complexity. With the exception of histidine, parameter estimates for essential amino acid removal by liver were 2-3-fold lower than for mammary gland. Infusion of an amino acid mixture into the mesenteric vein did not alter parameter estimates for removal of amino acids by the liver. Treatment of cows with bovine somatotropin resulted in changes in mammary parameter estimates for aspartate, glutamate, leucine, phenylalanine, glucose, and glycerol. Copyright © The Nutrition Society 1998 Mathematical modelling nationallicence Liver nationallicence Mammary gland nationallicence Hanigan M. D. Purina Mills, Inc., St Louis, MO 63144, USA France J. Institute of Grasslands and Environmental Research, North Wyke Research Station, Okehampton EX2 OSB, UK Wray-Cahen D. University of Reading, Whiteknights, Reading RG6 6AH, UK Beever D. E. University of Reading, Whiteknights, Reading RG6 6AH, UK Lobley G. E. Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK Reutzel L. Purina Mills, Inc., St Louis, MO 63144, USA Smith N. E. Purina Mills, Inc., St Louis, MO 63144, USA British Journal of Nutrition Cambridge University Press 79/1(1998-01), 63-78 0007-1145 79:1<63 1998 79 BJN https://doi.org/10.1079/BJN19980010 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1079/BJN19980010 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hanigan M. D. Purina Mills, Inc., St Louis, MO 63144, USA NATIONALLICENCE 700 1- France J. Institute of Grasslands and Environmental Research, North Wyke Research Station, Okehampton EX2 OSB, UK NATIONALLICENCE 700 1- Wray-Cahen D. University of Reading, Whiteknights, Reading RG6 6AH, UK NATIONALLICENCE 700 1- Beever D. E. University of Reading, Whiteknights, Reading RG6 6AH, UK NATIONALLICENCE 700 1- Lobley G. E. Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK NATIONALLICENCE 700 1- Reutzel L. Purina Mills, Inc., St Louis, MO 63144, USA NATIONALLICENCE 700 1- Smith N. E. Purina Mills, Inc., St Louis, MO 63144, USA NATIONALLICENCE 773 0- British Journal of Nutrition Cambridge University Press 79/1(1998-01), 63-78 0007-1145 79:1<63 1998 79 BJN CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge