caa a22 4500 388072989 CHVBK 20180307125153.0 cr unu---uuuuu 161130e199906 xx s 000 0 eng 10.1017/S0790966700005139 doi S0790966700005139 pii (NATIONALLICENCE)cambridge-10.1017/S0790966700005139 The utility of naming tests in the diagnosis of Alzheimer's disease [Elektronische Daten] [Robert F Coen, Nicholas Kidd, Aisling Denihan, Conal Cunningham, Irene Bruce, Fiona Buggy, Desmond O'Neill, J Bernard Walsh, Davis Coakley, Brian A Lawlor] Objectives: To evaluate the sensitivity of the CAMCOG naming subscale to anomia in Alzheimer's disease (AD) patients identified as anomic on the Boston Naming Test (BNT); and to compare the sensitivities of BNT, category (semantic) fluency (CF), and episodic memory (Delayed Word Recall, DWR) in detecting AD. Method: Data from 140 probable AD patients (NINCDS/ADRDA) were analysed. Anomic AD patients were identified (BNT) and the sensitivity to anomia of the CAMCOG naming subscale was calculated. Sensitivity (to AD) and specificity of the BNT, CF and DWR were compared in a subgroup of 60 patients age-matched to controls. Results: On BNT 81% of ADs were classified as anomic (87% specificity). Of these anomic ADs, 23 scored 6/6 on CAMCOG naming (sensitivity = 80%), and sensitivity fell to 30% using a 5/6 cut-off. Correlation between BNT and CAMCOG naming yielded Kendall's tau = 0.48 (p<0.0001). Compared to age-matched controls BNT correctly classified 70% of ADs and 87% of controls (overall accuracy = 77%). On CF 68% of ADs and 83% of controls were correctly classified (overall accuracy = 72%). BNT and CF were moderately correlated (r = 0.49, p<0.0001). DWR correctly classified 93% ADs and 98% controls (overall accuracy = 95%). Conclusions: Given its brevity, we recommend the inclusion of a split-half form of the BNT in screening test batteries for the detection of AD. The observed pattern of cognitive impairment is consistent with current models in which semantic memory deficits occur in AD only when the neuropathology extends beyond the entorhinal/hippocampal region to the temporal neocortex. Copyright © Cambridge University Press 1999 Alzheimer's disease nationallicence Anomia nationallicence Semantic memory nationallicence Episodic memory nationallicence Coen Robert F. aut Kidd Nicholas Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut Denihan Aisling Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut Cunningham Conal Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut Bruce Irene Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland Buggy Fiona Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland O'Neill Desmond Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut Walsh J Bernard Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut Coakley Davis Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut Lawlor Brian A. Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut Irish Journal of Psychological Medicine Cambridge University Press 16/2(1999-06), 43-46 0790-9667 16:2<43 1999 16 IPM https://doi.org/10.1017/S0790966700005139 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0790966700005139 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Coen Robert F. aut NATIONALLICENCE 700 1- Kidd Nicholas Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- Denihan Aisling Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- Cunningham Conal Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- Bruce Irene Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland NATIONALLICENCE 700 1- Buggy Fiona Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland NATIONALLICENCE 700 1- O'Neill Desmond Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- Walsh J Bernard Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- Coakley Davis Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- Lawlor Brian A. Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 773 0- Irish Journal of Psychological Medicine Cambridge University Press 16/2(1999-06), 43-46 0790-9667 16:2<43 1999 16 IPM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge