caa a22 4500 388084030 CHVBK 20180307125225.0 cr unu---uuuuu 161130e199906 xx s 000 0 eng 10.1017/S0022215100144433 doi S0022215100144433 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100144433 Prognostic factors in carcinoma of the larynx: relevance of DNA ploidy, S-fractions and localization of the tumour [Elektronische Daten] The influence of the cell cycle profile and the site of the primary tumour on the overall survival were examined in 36 patients with squamous cell carcinoma of the larynx. DNA ploidy (p = 0.0091), the overall proliferative activity (p = 0.0001), the overall proliferative activity of diploid tumour cells (p = 0.0017) and primary tumour site (p = 0.0008) were found to be significant single prognostic factors of the overall survival. Multivariate analysis showed that only the overall proliferative activity was prognostically significant (p = 0.013). The results of the study show that the supraglottic site of the tumours correlates significantly with DNA ploidy (p = 0.0334) and the overall proliferative activity of tumour cells (p = 0.0159), whereas the correlation with proliferative activity of diploid tumour cells (p = 0.1416) has not been confirmed by this study. Glottic tumours showed a prognostically significant correlation with the overall proliferative activity (p = 0.0037) and proliferative activity of diploid tumour (p = 0.0054). Such a prognostic correlation was not found for DNA ploidy (p = 0.6542). Copyright © JLO (1984) Limited 1999 Larynx nationallicence Carcinoma, squamous cell nationallicence DNA, neoplasm nationallicence Prognosis nationallicence Đanić Davorin Department of Otolaryngology, General Hospital ‘Dr. Josip Benčević, 35 000 Slavonski Brod, Croatia. Miličić Damir Department of Otolaryngology, General Hospital ‘Dr. Josip Benčević, 35 000 Slavonski Brod, Croatia. Prgomet Drago Department of Otolaryngology, General Hospital ‘Dr. Josip Benčević, 35 000 Slavonski Brod, Croatia. Leović Dinko Department of Otolaryngology, General Hospital ‘Dr. Josip Benčević, 35 000 Slavonski Brod, Croatia. The Journal of Laryngology & Otology Cambridge University Press 113/6(1999-06), 538-541 0022-2151 113:6<538 1999 113 JLO https://doi.org/10.1017/S0022215100144433 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100144433 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Đanić Davorin Department of Otolaryngology, General Hospital ‘Dr. Josip Benčević, 35 000 Slavonski Brod, Croatia NATIONALLICENCE 700 1- Miličić Damir Department of Otolaryngology, General Hospital ‘Dr. Josip Benčević, 35 000 Slavonski Brod, Croatia NATIONALLICENCE 700 1- Prgomet Drago Department of Otolaryngology, General Hospital ‘Dr. Josip Benčević, 35 000 Slavonski Brod, Croatia NATIONALLICENCE 700 1- Leović Dinko Department of Otolaryngology, General Hospital ‘Dr. Josip Benčević, 35 000 Slavonski Brod, Croatia NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 113/6(1999-06), 538-541 0022-2151 113:6<538 1999 113 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge