caa a22 4500 388084189 CHVBK 20180307125225.0 cr unu---uuuuu 161130e199908 xx s 000 0 eng 10.1017/S0022215100145050 doi S0022215100145050 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100145050 Ex juvantibus approach for chronic posterior laryngitis: results of short-term pantoprazole therapy [Elektronische Daten] The aim of this study was to investigate whether patients with chronic posterior laryngitis and symptoms of gastro-pharyngeal reflux benefit from a six-week therapy with pantoprozole. Twenty-nine out-patients with voice disorders (case history of at least two months) and simultaneous symptoms of gastropharyngeal reflux were recruited for this study. At the entry to the study a symptom questionnaire and a videolaryngo/stroboscopy were completed. The symptom questionnaire and the video-laryngo/stroboscopy were repeated after the six weeks of therapy with pantoprazole 40 mg once a day and again six weeks and three months after this follow-up, during which time the patient was without therapy. Hoarseness, globus pharyngeus, sore throat, heartburn, and coughing were the symptoms which showed a significant (p<0.05) recovery at the follow-ups (mean of hoarseness index: 7.28 to 0.92; mean of globus pharyngeus index: 3.14 to 0.58; mean of heartburn index: 2.86 to 0.5; mean of cough index: 1.72 to 0.25; mean of throat soreness index: 1.72 to 0.15). Laryngoscopy scores of the posterior laryngeal region, the glottic and the supraglottic region showed statistically significant improvement (p<0.05) after the treatment with pantoprazole. The therapeutic effect exceeded the drug administration until the last follow-up (after three months). The medication was tolerated without side-effects in all patients. A primary (ex juvantibus) therapy with proton pump inhibitors seems to be a therapeutic option for patients with long-lasting chronic inflammation of the larynx not responding to common therapy. In this case a six-week course of treatment has been shown to be sufficient. Copyright © JLO (1984) Limited 1999 Laryngitis nationallicence Voice disorders nationallicence Gastrooesophageal reflux nationallicence Proton pump nationallicence Drug therapy nationallicence Habermann Walter Department of ENT, University of Graz, Medical School, Austria. Eherer Andreas Department of Internal Medicine University of Graz, Medical School, Austria. Lindbichler Franz Department of Radiology, University of Graz, Medical School, Austria. Raith Johann Department of Radiology, University of Graz, Medical School, Austria. Friedrich Gerhard Department of ENT, University of Graz, Medical School, Austria. The Journal of Laryngology & Otology Cambridge University Press 113/8(1999-08), 734-739 0022-2151 113:8<734 1999 113 JLO https://doi.org/10.1017/S0022215100145050 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100145050 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Habermann Walter Department of ENT, University of Graz, Medical School, Austria NATIONALLICENCE 700 1- Eherer Andreas Department of Internal Medicine University of Graz, Medical School, Austria NATIONALLICENCE 700 1- Lindbichler Franz Department of Radiology, University of Graz, Medical School, Austria NATIONALLICENCE 700 1- Raith Johann Department of Radiology, University of Graz, Medical School, Austria NATIONALLICENCE 700 1- Friedrich Gerhard Department of ENT, University of Graz, Medical School, Austria NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 113/8(1999-08), 734-739 0022-2151 113:8<734 1999 113 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge