caa a22 4500 38808460X CHVBK 20180307125226.0 cr unu---uuuuu 161130e199904 xx s 000 0 eng 10.1017/S0022215100143907 doi S0022215100143907 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100143907 Sequential magnetic resonance imaging analysis of the maxillary sinuses: implications for a model of gene therapy in cystic fibrosis [Elektronische Daten] Serial maxillary sinus aminoglycoside lavage is an adjunctive technique increasingly employed in a variety of areas in cystic fibrosis (CF). It may be helpful in reducing revision rates for sinus surgery, in lowering rates of bronchial pseudomonal colonization after lung transplantation and in the evolving field of gene therapy for CF. The goal of this study was to assess the utility of the maxillary sinus as a model for gene transfer in cystic fibrosis. We performed serial maxillary sinus lavage, in accordance with published protocols, using tobramycin in a randomized series of five CF subjects. Lavage was performed for up to 10 days and sequential magnetic resonance imaging (MRI) scans were taken at zero, 10, 30, 60, 120 and 180 days. The 30 MRI scans were blindly scored by two examiners on the parameters of maxillary sinus aeration, averaged over the five time intervals, was significantly improved (p<0.05) in the lavaged sinus. This study provides the first systematic image-based measure of efficacy of maxillary sinus aminoglycoside lavage, a major element of a number of clinical protocols used in the treatment of CF. The prolonged increase in aeration after lavage suggests that any further improvement potentially achievable after gene transfer would be difficult to detect, limiting the value of this system as a model of clinical efficacy of gene transfer in CF. Copyright © JLO (1984) Limited 1999 Cystic fibrosis nationallicence Gene therapy nationallicence Maxillary sinus nationallicence Graham Scott M. Division of Head and Neck Surgery, Department of Internal Medicine, University of Iowa City, Iowa, USA. Launspach Janice L. Department of Otolaryngology - Head and Neck Surgery and the Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa City, Iowa, USA. Welsh Michael J. Department of Otolaryngology - Head and Neck Surgery and the Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa City, Iowa, USA. Zabner Joseph Department of Otolaryngology - Head and Neck Surgery and the Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa City, Iowa, USA. The Journal of Laryngology & Otology Cambridge University Press 113/4(1999-04), 329-335 0022-2151 113:4<329 1999 113 JLO https://doi.org/10.1017/S0022215100143907 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100143907 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Graham Scott M. Division of Head and Neck Surgery, Department of Internal Medicine, University of Iowa City, Iowa, USA NATIONALLICENCE 700 1- Launspach Janice L. Department of Otolaryngology - Head and Neck Surgery and the Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa City, Iowa, USA NATIONALLICENCE 700 1- Welsh Michael J. Department of Otolaryngology - Head and Neck Surgery and the Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa City, Iowa, USA NATIONALLICENCE 700 1- Zabner Joseph Department of Otolaryngology - Head and Neck Surgery and the Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa City, Iowa, USA NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 113/4(1999-04), 329-335 0022-2151 113:4<329 1999 113 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge