caa a22 4500 388085177 CHVBK 20180307125228.0 cr unu---uuuuu 161130e199912 xx s 000 0 eng 10.1017/S0022215100157998 doi S0022215100157998 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100157998 Langerhans' cell histiocytosis - A rare cause of sudden onset unilateral sensorineural hearing loss [Elektronische Daten] Langerhans' cell histiocytosis is a rare disorder of unknown aetiology in which pathological Langerhans' cells accumulate and destroy local tissue. We report a 38-year-old female who presented with a sudden onset of left sensormeural hearing loss. Magnetic resonance imaging (MRI) revealed a contrast-enhancing lesion in the left mastoid and a second lesion in the hypothalamus. Following left mastoid exploration and biopsy a definitive diagnosis of Langerhans' cell histiocytosis was made and the patient was treated with external beam radiotherapy. Subsequent right femur and right mastoid involvement were successfully treated with steroids and cytotoxic chemotherapy. At one year follow-up the patient had residual left-sided sensorineural hearing loss with normal hearing in the right ear. To our knowledge, Langerhans' cell histiocytosis has not been previously reported as a cause of unilateral sudden onset sensorineural hearing loss. It should be considered in the differential diagnosis of this condition. Copyright © JLO (1984) Limited 1999 Hearing loss, sensorineural nationallicence Histiocytosis, Langerhans' cell nationallicence Hore I. Department of Otolaryngology, The Royal Free Hospital, London, UK. Mitchell R. B. Department of Otolaryngology, The Royal Free Hospital, London, UK. Radcliffe G. Department of Otolaryngology, The Royal Free Hospital, London, UK. Quiney R. Department of Otolaryngology, The Royal Free Hospital, London, UK. Walker T. Department of Histopathology, The Royal Free Hospital, London, UK. The Journal of Laryngology & Otology Cambridge University Press 113/12(1999-12), 1098-1100 0022-2151 113:12<1098 1999 113 JLO https://doi.org/10.1017/S0022215100157998 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100157998 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hore I. Department of Otolaryngology, The Royal Free Hospital, London, UK NATIONALLICENCE 700 1- Mitchell R. B. Department of Otolaryngology, The Royal Free Hospital, London, UK NATIONALLICENCE 700 1- Radcliffe G. Department of Otolaryngology, The Royal Free Hospital, London, UK NATIONALLICENCE 700 1- Quiney R. Department of Otolaryngology, The Royal Free Hospital, London, UK NATIONALLICENCE 700 1- Walker T. Department of Histopathology, The Royal Free Hospital, London, UK NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 113/12(1999-12), 1098-1100 0022-2151 113:12<1098 1999 113 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge