caa a22 4500 388085207 CHVBK 20180307125228.0 cr unu---uuuuu 161130e199912 xx s 000 0 eng 10.1017/S0022215100157901 doi S0022215100157901 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100157901 Frosh Adam Department of Otorhinolaryngology, St Mary's Hospital, London, UK. Prions and the ENT surgeon [Elektronische Daten] [Adam Frosh] Recent developments in our understanding of prion diseases have raised concerns for the public health. There is now compelling evidence that the transmissible agent for variant Creutzfeldt-Jakob disease (vCJD) in affected individuals is accumulated in lymphoreticular tissues such as the appendix and tonsils. This agent demonstrates a remarkable resistance to standard methods of sterilisation used in hospital sterile services departments. The possible implications this has on the safety of surgical instruments in ENT and other surgical practice is discussed. This review also outlines the history of our understanding of prion diseases and describes the development of a diagnostic test for vCJD in the living patient by pharyngeal tonsil biopsy. Copyright © JLO (1984) Limited 1999 Prions nationallicence Surgical instruments, adverse effects nationallicence Creutzfeldt-Jakob syndrome nationallicence Spongiform encephalopathy nationallicence Tonsillectomy nationallicence The Journal of Laryngology & Otology Cambridge University Press 113/12(1999-12), 1064-1067 0022-2151 113:12<1064 1999 113 JLO https://doi.org/10.1017/S0022215100157901 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100157901 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Frosh Adam Department of Otorhinolaryngology, St Mary's Hospital, London, UK NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 113/12(1999-12), 1064-1067 0022-2151 113:12<1064 1999 113 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge