caa a22 4500 388086149 CHVBK 20180307125230.0 cr unu---uuuuu 161130e199905 xx s 000 0 eng 10.1017/S0022215100144184 doi S0022215100144184 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100144184 Prognostic value of p53 expression and histopathological parameters in squamous cell carcinoma of oral tongue [Elektronische Daten] The TNM staging system is helpful but not enough to determine prognosis of the patients with squamous cell carcinoma of the oral tongue. T -stage alone is not suggestive for prediction of occult nodal metastases. For this reason, histopathological examination of 70 patients with squamous cell carcinoma of the oral tongue was done retrospectively. The histological differentiation, tumour thickness, perineural and lymphovascular space invasions, the amount of lymphocyte infiltration and pattern of tumour invasion were examined. Immunohistochemical examination was used to determine p53 immunoreactivity as well. The effect of these histopathological parameters and p53 immunoreactivity on nodal metastases and locoregional recurrence were analyzed using the chi-squared test. In terms of nodal metastases the only statistically significant difference between the two groups was tumour thickness, either <9 mm or >9 mm (p<0.05, χ2 = 17.182). Tumour thickness, perineural invasion, lymphovascular space invasion, the amount of lymphocyte infiltration all correlated statistically with locoregional recurrence (p<0.05, χ2 = 6.293 for tumour thickness; p<0.06, p = 0.054 for perineural invasion; p<0.05, χ2 = 8.689 for lymphovascular space invasion; p<0.05, χ2 = 5.320 for lymphocyte infiltration). The immunoreactivity of p53 correlated significantly with larger primary tumour size (p<0.05, χ2 = 5.440), lymph node metastases (p<0.05, χ2 = 4.093) and with pathological tumour stage (p<0.05, χ2 = 5.713). These results reveal that the above-mentioned histological parameters and p53 determination could be used for handling a specimen from an anterior tongue squamous cell carcinoma. Copyright © JLO (1984) Limited 1999 Mouth neoplasms nationallicence Squamous cell carcinoma nationallicence Genes, p53 nationallicence Prognosis nationallicence Ünal Ömer Faruk Department of Otolaryngology, Head & Neck Surgery Hacettepe University Medical School, Ankara, Turkey. Ayhan Ayse Department of Pathology, Hacettepe University Medical School, Ankara, Turkey. Hoşal Ali Şefik Department of Otolaryngology, Head & Neck Surgery Hacettepe University Medical School, Ankara, Turkey. The Journal of Laryngology & Otology Cambridge University Press 113/5(1999-05), 446-450 0022-2151 113:5<446 1999 113 JLO https://doi.org/10.1017/S0022215100144184 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100144184 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ünal Ömer Faruk Department of Otolaryngology, Head & Neck Surgery Hacettepe University Medical School, Ankara, Turkey NATIONALLICENCE 700 1- Ayhan Ayse Department of Pathology, Hacettepe University Medical School, Ankara, Turkey NATIONALLICENCE 700 1- Hoşal Ali Şefik Department of Otolaryngology, Head & Neck Surgery Hacettepe University Medical School, Ankara, Turkey NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 113/5(1999-05), 446-450 0022-2151 113:5<446 1999 113 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge