caa a22 4500 38809463X CHVBK 20180307125301.0 cr unu---uuuuu 161130e199912 xx s 000 0 eng 10.1017/S1092852900006799 doi S1092852900006799 pii (NATIONALLICENCE)cambridge-10.1017/S1092852900006799 Altered CSF 5-HIAA Disposition in Pathologic Male Gamblers [Elektronische Daten] Previous reports concerning the cerebrospinal fluid (CSF) of pathologic gamblers have described disturbed norepinephrine and dopamine (but not serotonin) functioning in the central nervous system. We analyzed neurotransmitter metabolites in two consecutive 6-mL samples of CSF obtained from 10 pathologic male gamblers punctured at the L4-5 level following 8 hours of fasting along with strict bed rest. Data were compared with those for healthy male controls. In conformity with findings in healthy male controls, we found gradients in CSF 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA), but not 4-hydroxy-3-methoxyphenyl glycol (HMPG). Expressing the CSF concentrations as nmol x L-1 x min-1 of tapping time (an estimate of the mass flow through the needle), the levels of 5-HIAA and HMPG (but not HVA) were found to be significantly lower in gamblers. Levels of 5-HIAA and HVA showed a significant correlation in gamblers but not in healthy controls. Taking tapping time into account, the CSF levels of HMPG and 5-HIAA were significantly lower in gamblers. We concluded that, in light of previous CSF findings of disturbed norepinephrine and dopamine function, altered indolamine function cannot be fully ruled out. Copyright © Cambridge University Press 1999 Nordin Conny Eklundh Thomas CNS Spectrums Cambridge University Press 4/12(1999-12), 25-33 1092-8529 4:12<25 1999 4 CNS https://doi.org/10.1017/S1092852900006799 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1092852900006799 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nordin Conny NATIONALLICENCE 700 1- Eklundh Thomas NATIONALLICENCE 773 0- CNS Spectrums Cambridge University Press 4/12(1999-12), 25-33 1092-8529 4:12<25 1999 4 CNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge