caa a22 4500 388095040 CHVBK 20180307125302.0 cr unu---uuuuu 161130e199905 xx s 000 0 eng 10.1017/S1092852900007410 doi S1092852900007410 pii (NATIONALLICENCE)cambridge-10.1017/S1092852900007410 Marazziti Donatella Obsessive-Compulsive Disorder: Experimental Pharmacology [Elektronische Daten] [Donatella Marazziti] There is evidence supporting the presence of abnormalities in certain neurotransmitters, such as dopamine and noradrenaline, and in neuropeptides and other mechanisms, such as the immune system in patients with obsessive-compulsive disorder (OCD). However, the findings implicating serotonin (5-hydroxytryptamine [5-HT]) in the pathophysiology of OCD are increasing at a rate not found in any other psychiatric disorder. These abundant findings foster numerous complex questions that await answers. For example, which 5-HT receptor subtypes or other subcomponents of the 5-HT system are principally involved in OCD pathophysiology, and how do they interact with dysfunctions of other systems? In the search for answers to these critical questions, experimental pharmacology represents a key tool for approaching the complexity of the involvement of 5-HT in OCD, and also suggests new potential therapeutic targets. This article summarizes, in part, the presentations and the discussion of the symposium, "Experimental Pharmacology in OCD,” which was held during the Third International OCD Conference meeting in Madeira, Portugal, in September 1998. Copyright © Cambridge University Press 1999 CNS Spectrums Cambridge University Press 4/S3(1999-05), 41-45 1092-8529 4:S3<41 1999 4 CNS https://doi.org/10.1017/S1092852900007410 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1092852900007410 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Marazziti Donatella NATIONALLICENCE 773 0- CNS Spectrums Cambridge University Press 4/S3(1999-05), 41-45 1092-8529 4:S3<41 1999 4 CNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge